COVID toes: Pernio-like lesions

Area of Science:

• Dermatology
• Infectious Diseases
• Virology

Background:

• The COVID-19 pandemic, caused by SARS-CoV-2, has led to over 40 million infections globally.
• Various cutaneous manifestations associated with SARS-CoV-2 infection have been reported.
• A specific rash, termed 'COVID toes,' presents as a pernio-like eruption.

Purpose of the Study:

• To review published case series detailing the clinical presentation of 'COVID toes.'
• To explore potential pathogenic mechanisms underlying the development of this COVID-19-related skin condition.

Main Methods:

• Systematic review of published literature on 'COVID toes.'
• Analysis of case series focusing on dermatological symptoms of SARS-CoV-2.
• Examination of studies investigating the pathophysiology of viral skin manifestations.

Main Results:

• 'COVID toes' are characterized by a pernio-like rash.
• The eruption is considered a cutaneous manifestation of SARS-CoV-2 infection.
• Research is ongoing to elucidate the exact mechanisms causing this symptom.

Conclusions:

• 'COVID toes' represent a notable dermatological sign of SARS-CoV-2 infection.
• Understanding the pathogenesis of 'COVID toes' may offer insights into broader viral-induced inflammatory responses.
• Further research is needed to confirm the link and understand the underlying mechanisms.