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Venous thromboembolism: Recent advancement and future perspective.
Yugo Yamashita1, Takeshi Morimoto2, Takeshi Kimura1
1Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Journal of Cardiology
|September 14, 2021
Summary
Venous thromboembolism (VTE) management is evolving with direct oral anticoagulants (DOACs). Optimal anticoagulation duration balances recurrence and bleeding risks, with ongoing research into complex cases like cancer-associated VTE.
Area of Science:
- Cardiology
- Hematology
- Clinical Medicine
Background:
- Venous thromboembolism (VTE) prevalence is increasing globally, particularly in Asian countries like Japan.
- Recent advancements in VTE management include the introduction of direct oral anticoagulants (DOACs) and updated treatment strategies.
- Despite guideline changes, Japan shows high utilization of thrombolysis and IVC filters, contrasting with current evidence.
Purpose of the Study:
- To review recent advances in VTE management.
- To describe the current VTE treatment landscape in Japan.
- To discuss future research directions and challenges in VTE care.
Main Methods:
- Review of recent clinical trials and landmark studies in VTE treatment.
- Analysis of current VTE management guidelines and their application.
- Examination of domestic trends and practices in Japan regarding VTE therapies.
Main Results:
- DOACs offer a safer profile for home treatment and extended anticoagulation.
- Current guidelines advise against routine thrombolysis or IVC filter use, yet their application remains high in Japan.
- Determining optimal anticoagulation duration requires individual risk assessment for recurrence and bleeding.
Conclusions:
- VTE management has significantly advanced, with DOACs enabling safer and more accessible treatments.
- Addressing persistent regional variations in treatment practices, such as in Japan, is crucial.
- Further research is needed for complex VTE scenarios, including cancer-associated and minor VTE.
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