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Updated: Oct 20, 2025

Isolation of Human Islets from Partially Pancreatectomized Patients
Published on: July 30, 2011
The Bihormonal Bionic Pancreas Improves Glycemic Control in Individuals With Hyperinsulinism and Postpancreatectomy
Arpana Rayannavar1, Lauren M Mitteer1, Courtney A Balliro2
1Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, PA.
Objective:
To determine whether the bihormonal bionic pancreas (BHBP) improves glycemic control and reduces hypoglycemia in individuals with congenital hyperinsulinism (HI) and postpancreatectomy diabetes (PPD) compared with usual care (UC).
Research Design And Methods:
Ten subjects with HI and PPD completed this open-label, crossover pilot study. Coprimary outcomes were mean glucose concentration and time with continuous glucose monitoring (CGM) glucose concentration <3.3 mmol/L.
Results:
Mean (SD) CGM glucose concentration was 8.3 (0.7) mmol/L in the BHBP period versus 9 (1.8) mmol/L in the UC period (P = 0.13). Mean (SD) time with CGM glucose concentration <3.3 mmol/L was 0% (0.002) in the BHBP period vs. 1.3% (0.018) in the UC period (P = 0.11).
Conclusions:
Relative to UC, the BHBP resulted in comparable glycemic control in our population.
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