Related Experiment Video
Updated: Oct 20, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Effect of Statins on the Risk of Different Stages of Prostate Cancer: A Meta-Analysis
Yun Li1, Xuan Cheng1, Jia-Lian Zhu1
1Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha, China.
Introduction:
The aim of this article was to investigate the relationship between statins and the risk of different stages or grades of prostate cancer.
Methods:
A comprehensive literature search was performed for articles published until December 18, 2020, on the PubMed, Embase, and the Cochrane Library databases. The pooled relative risk (RR) and 95% confidence interval (CI) were then analyzed using the STATA.16.0 software.
Results:
A total of 588,055 patients from 14 studies were included in the analysis. We found that the use of statins expressed a significant correlation with a lower risk of advanced prostate cancer (RR = 0.81, 95% CI: 0.73-0.91; RR = 0.86, 95% CI: 0.75-0.99, respectively). However, no evidence suggested that the use of statins was beneficial for the prevention of localized prostate cancer incidence. Similarly, the pooled results also revealed no association between the use of statins and the risk of high-grade and low-grade prostate cancer.
Conclusion:
It has been found that the use of statins is associated with a lower risk of advanced prostate cancer but was not related to the risk of localized, low-grade, or high-grade prostate cancer.
Related Concept Videos
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Atherosclerosis III: Management
Cancer Survival Analysis
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

