Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

581
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
581
Antihypertensive Drugs: Direct Renin Inhibitors01:25

Antihypertensive Drugs: Direct Renin Inhibitors

925
The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
925
Blood and Nerve Supply to the Kidney01:18

Blood and Nerve Supply to the Kidney

2.6K
The kidneys are vital organs responsible for filtering and cleaning blood, removing waste products, and regulating electrolyte levels. To perform these essential functions, they require a constant and robust blood supply.
Bloody Supply to the Kidneys:
The kidneys receive their blood supply from the renal arteries, which branch off from the abdominal aorta—the main artery supplying the abdomen and lower body. The renal arteries enter the kidneys at the hilum, a notch on the medial side of...
2.6K
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

540
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
540

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neural Upregulation of SGLT2-MAP17-PDZK1 Complex in Kidneys of Rats With Heart Failure.

Hypertension (Dallas, Tex. : 1979)·2026
Same author

Inhibition of Pyk2 prevents Cx43 remodeling and cardiomyocyte injury during hypoxic and adrenergic stress.

Journal of molecular and cellular cardiology·2025
Same author

Degradation of nNOS in the PVN of Rats With Heart Failure: Role of CHIP.

Hypertension (Dallas, Tex. : 1979)·2025
Same author

Stellate Ganglia: A Key Therapeutic Target for Malignant Ventricular Arrhythmia in Heart Disease.

Circulation research·2025
Same author

Sodium-Glucose Cotransporter 2 Inhibitors as Potential Antioxidant Therapeutic Agents in Cardiovascular and Renal Diseases.

Antioxidants (Basel, Switzerland)·2025
Same author

Downregulation of neuronal nitric oxide synthase (nNOS) within the paraventricular nucleus in Ins2<sup>Akita</sup>-type-1 diabetic mice contributes to sympatho-excitation.

Nitric oxide : biology and chemistry·2024

Related Experiment Video

Updated: Oct 20, 2025

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

3.6K

Renal denervation based on experimental rationale.

Kenichi Katsurada1,2, Yukako Ogoyama1, Yasushi Imai1,2

  • 1Division of Cardiovascular Medicine, Department of Internal Medicine, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.

Hypertension Research : Official Journal of the Japanese Society of Hypertension
|September 14, 2021
PubMed
Summary

Excessive sympathetic nervous system activation contributes to hypertension and heart failure. Renal denervation can suppress this outflow, offering benefits for these conditions.

Keywords:
Heart failureHypertensionParaventricular nucleusRenal denervationSympathetic nervous system

More Related Videos

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
04:37

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

404
Novel Approach for Simultaneous Recording of Renal Sympathetic Nerve Activity and Blood Pressure with Intravenous Infusion in Conscious, Unrestrained Mice.
11:08

Novel Approach for Simultaneous Recording of Renal Sympathetic Nerve Activity and Blood Pressure with Intravenous Infusion in Conscious, Unrestrained Mice.

Published on: February 14, 2018

10.4K

Related Experiment Videos

Last Updated: Oct 20, 2025

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

3.6K
Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
04:37

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

404
Novel Approach for Simultaneous Recording of Renal Sympathetic Nerve Activity and Blood Pressure with Intravenous Infusion in Conscious, Unrestrained Mice.
11:08

Novel Approach for Simultaneous Recording of Renal Sympathetic Nerve Activity and Blood Pressure with Intravenous Infusion in Conscious, Unrestrained Mice.

Published on: February 14, 2018

10.4K

Area of Science:

  • Neuroscience
  • Cardiovascular Physiology

Background:

  • Sympathetic nervous system overactivation is key in hypertension and heart failure.
  • The paraventricular nucleus (PVN) and rostral ventrolateral medulla regulate sympathetic outflow.
  • Peripheral signals (sodium, angiotensin II) and central factors (brain renin-angiotensin system, nitric oxide/reactive oxygen species balance, brain inflammation) influence sympathetic activity.

Purpose of the Study:

  • To investigate the role of the central nervous system in sympathetic regulation.
  • To explore the impact of renal denervation on sympathetic outflow and cardiovascular health.

Main Methods:

  • Integration of peripheral and central signals within the PVN.
  • Analysis of afferent input via renal nerves.
  • Assessment of efferent outputs from the PVN to the kidney.

Main Results:

  • Renal denervation disrupts kidney-to-PVN afferent pathways and PVN-to-kidney efferent pathways.
  • This disruption leads to suppression of sympathetic outflow.
  • Beneficial effects were observed in models of hypertension and heart failure.

Conclusions:

  • The central nervous system, particularly the PVN, is crucial for sympathetic regulation.
  • Renal denervation effectively modulates sympathetic outflow.
  • Renal denervation shows therapeutic potential for hypertension and heart failure.