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Abnormal hippocampal substructure volume in insomnia disorder.

Longmao Chen1,2, Ziqiang Shao1,2, Wangrui Lei3

  • 1School of Life Science and Technology, Xidian University, 266 Xinglong Section of Xifeng Road, Xi'an, Shaanxi, 710126, People's Republic of China.

Brain Imaging and Behavior
|September 14, 2021
PubMed
Summary

Structural brain imaging reveals reduced fimbria volume in individuals with insomnia disorders (ID). This finding provides a potential imaging marker for insomnia, differentiating it from healthy controls (HC).

Keywords:
FreeSurfer6.0HippocampusInsomnia disorderSubstructure

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Area of Science:

  • Neuroimaging
  • Structural MRI
  • Sleep Medicine

Background:

  • Conflicting findings exist regarding hippocampal volume abnormalities in insomnia disorders (ID).
  • Hippocampal substructures are functionally distinct and can be analyzed individually.
  • Detailed examination of hippocampal substructures may reveal specific imaging markers for ID.

Purpose of the Study:

  • To investigate differences in hippocampal substructure volumes between individuals with insomnia disorders (ID) and healthy controls (HC).
  • To identify specific hippocampal substructures that can serve as imaging markers for ID.

Main Methods:

  • Utilized FreeSurfer6.0's automated hippocampal substructure module on T1-weighted MRI scans.
  • Analyzed 12 hippocampal substructures in 22 IDs and 30 HC.
  • Performed volumetric assessment at the hippocampal substructure level and correlation analyses.

Main Results:

  • Significantly reduced bilateral fimbria volume was observed in IDs compared to HC (p < 0.05/12, Bonferroni corrected).
  • No significant difference was found in total hippocampal volume between groups.
  • Left total hippocampal volume negatively correlated with Pittsburgh Sleep Quality Index (PSQI) scores.
  • Bilateral fimbria volume showed negative correlations with clinical variables (PSQI, SDS, SAS) across all subjects.

Conclusions:

  • Distinct differences in hippocampal substructure volumes exist between individuals with insomnia disorders and healthy controls.
  • Reduced bilateral fimbria volume represents a potential structural imaging marker for the pathology of insomnia.
  • These findings contribute to a more accurate understanding of the neurobiological underpinnings of insomnia.