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Related Concept Videos

Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Related Experiment Video

Updated: Oct 20, 2025

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
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Primary sellar melanocytoma.

M Claus1, M Van Der Linden2, J Van Dorpe2

  • 1Department of Endocrinology, Ghent University Hospital, C. Heymanslaan 10, 9000, Ghent, Belgium. Mathieu.Claus@uzgent.be.

Pituitary
|September 14, 2021
PubMed
Summary
This summary is machine-generated.

Sellar melanocytomas, rare pituitary tumors, cause symptoms like vision loss. Complete surgical resection is the primary treatment, with radiation therapy for residual or recurrent tumors.

Keywords:
LeptomeningesPituitary tumorSellar melanocytomaTranssphenoidal surgery

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Area of Science:

  • Neuro-oncology
  • Endocrinology
  • Pathology

Background:

  • Sellar melanocytoma is a benign neoplasm originating from melanocytes in the pituitary gland's surrounding leptomeninges.
  • These tumors are rare and can present with mass effects on adjacent structures.

Purpose of the Study:

  • To review all published cases of sellar melanocytoma.
  • To summarize clinical presentation, treatment, and diagnostic challenges.

Main Methods:

  • Comprehensive literature search of Medline and Embase databases.
  • Inclusion of case reports and case series detailing sellar melanocytic masses.

Main Results:

  • Fourteen cases of sellar melanocytoma were identified.
  • Common symptoms included pituitary dysfunction and visual impairment due to mass effect.
  • Transsphenoidal resection was the initial treatment for all patients.
  • Distinguishing melanocytoma from melanoma can be challenging based solely on pathology.

Conclusions:

  • Genetic analysis, including GNAQ/GNA11 or BRAF mutations, aids in differentiating CNS melanocytoma from metastatic melanoma.
  • Complete surgical resection is the preferred initial management.
  • Radiotherapy is recommended for incomplete resection or tumor recurrence.