Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anionic Chain-Growth Polymerization: Overview01:20

Anionic Chain-Growth Polymerization: Overview

2.2K
The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...
2.2K
Local Anesthetics: Chemistry and Structure-Activity Relationship01:27

Local Anesthetics: Chemistry and Structure-Activity Relationship

5.8K
Local anesthetics (LAs) are drugs that induce a temporary loss of sensation in a limited body area, preventing pain. Cocaine was the first local anesthetic discovered in the late 19th century. Cocaine is a benzoic acid ester obtained from the leaves of coca shrubs and was often used for its psychotropic effects. Cocaine was first isolated in 1860 by Albert Niemann. Sigmund Freud studied the physiological actions of cocaine. Carl Koller later introduced it into clinical practice in 1884 as a...
5.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeted intracellular glucose oxidase nanotherapy enables single-dose treatment of prostate cancer.

International journal of pharmaceutics·2026
Same author

Systematic Design of Molecularly Imprinted Polymers for Triclosan Using Design of Experiments and Molecular Dynamics Simulations.

Polymers·2026
Same author

Polylactic acid/MXene composites: A journey from structural properties to emerging multifunctional applications.

International journal of biological macromolecules·2026
Same author

Retraction notice to "Green products from herbal medicine wastes by subcritical water treatment" [J Hazard Mater 424 (2022) 127294].

Journal of hazardous materials·2026
Same author

Corrigendum to "Advances in quantum dot-based fluorescence sensors for environmental and biomedical detection" [Talanta 294 (2025) 128176].

Talanta·2026
Same author

Correction to "Graphene-Based Polymeric Microneedles for Biomedical Applications: A Comprehensive Review".

ACS applied bio materials·2026

Related Experiment Video

Updated: Oct 20, 2025

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
12:02

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

Published on: November 2, 2016

12.3K

Advanced Delivery Systems Based on Lysine or Lysine Polymers.

Saeed Manouchehri1, Payam Zarrintaj1, Mohammad Reza Saeb2

  • 1School of Chemical Engineering, Oklahoma State University, 420 Engineering North, Stillwater, Oklahoma 74078, United States.

Molecular Pharmaceutics
|September 14, 2021
PubMed
Summary

Polylysine, a versatile polymer, offers enhanced intracellular drug delivery. Its unique properties enable smart, stimuli-responsive systems for improved therapeutic agent transport and imaging agent performance.

Keywords:
Drug DeliveryGene DeliveryPolylysineProtein Delivery, Stimuli-responsive

More Related Videos

Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery
08:09

Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery

Published on: August 6, 2019

5.9K
A Facile Protocol to Generate Site-Specifically Acetylated Proteins in Escherichia Coli
11:08

A Facile Protocol to Generate Site-Specifically Acetylated Proteins in Escherichia Coli

Published on: December 9, 2017

7.2K

Related Experiment Videos

Last Updated: Oct 20, 2025

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
12:02

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

Published on: November 2, 2016

12.3K
Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery
08:09

Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery

Published on: August 6, 2019

5.9K
A Facile Protocol to Generate Site-Specifically Acetylated Proteins in Escherichia Coli
11:08

A Facile Protocol to Generate Site-Specifically Acetylated Proteins in Escherichia Coli

Published on: December 9, 2017

7.2K

Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Polymer Chemistry

Background:

  • Polylysine is a cationic macromolecule that interacts electrostatically with cells, facilitating efficient intracellular delivery.
  • Its inherent pH-responsiveness can be augmented with various functional groups to create stimuli-responsive drug delivery platforms.

Purpose of the Study:

  • To comprehensively review the application of lysine residues, peptides, and polymers in drug delivery systems.
  • To provide insights into the design and manufacturing of robust lysine-based delivery platforms.

Main Methods:

  • Review of existing literature on polylysine and lysine-based materials in drug delivery.
  • Analysis of functionalization strategies to impart stimuli-responsive properties (pH, temperature, hypoxia, redox, enzyme).
  • Evaluation of polylysine's role in delivering diverse cargos and enhancing imaging agents.

Main Results:

  • Polylysine enables intracellular delivery of small-molecule drugs, genes, proteins, and imaging agents.
  • Functionalization enhances polylysine's responsiveness to multiple stimuli, improving therapeutic agent delivery.
  • Polylysine modification of contrast agents increases cellular uptake and stability.

Conclusions:

  • Lysine-based materials, particularly polylysine, are promising for advanced drug delivery.
  • Stimuli-responsive functionalization offers tailored intracellular delivery strategies.
  • Further development in design and manufacturing can optimize these platforms for clinical applications.