Related Experiment Videos
The influence of anxiety and pain sensitivity on experimental pain in man
Beat Von Graffenried1, Rolf Adler, Klaus Abt
1(B.v.G., E.N. and R.S.) Experimental Therapeutics, Biological and Medical Research, Pharmaceutical Division, Sandoz Ltd., CH-4002 BasleSwitzerland (R.A.) Medical Faculty of the University of Berne, Department of Medicine, University of Berne, CH-3000 BerneSwitzerland (K.A.) Department of Biostatistics, J.W. Goethe University, D-6 Frankfurt am Main 70 G.F.R.
Abstract:
A study was made of a number of factors that might be responsible for the unreliable results obtained in experimentally induced pain in man. In a randomised, double-blind, cross-over study on 32 healthy, male volunteers, the ischaemic pain test [14] and several psychological tests were performed. The influence of the following factors on the pain test results were examined: (a) ingestion of single, oral doses of 1000 mg aspirin (ASA) and placebo, (b) practice effect, (c) initial pain sensitivity, (d) anxiety, coping behaviour, attitude to the experiment and personality factors. The analgesic activity of ASA could not be demonstrated. An interaction between primary pain sensitivity and the sequence of drug administration was found. Furthermore, anxiety had a marked influence on the test results. Using experimental pain models reliable results are not to be expected as anxiety fluctuates intra- and interindividually in an unpredictable and uncontrollable manner.