Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Optic nerve in diabetes mellitus: a case control study.

L Giarelli1, G Grandi, M Delendi

  • 1Institute of Pathological Anatomy and Histology, University of Trieste, Italy.

Metabolic, Pediatric, and Systemic Ophthalmology (New York, N.Y. : 1985)
|January 1, 1986
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Improving access to postpartum contraception - a review of global guidelines with ESCRH consensus recommendations for Europe.

The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception·2025
Same author

The difficult journey to treatment for women suffering from heavy menstrual bleeding: a multi-national survey.

The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception·2021
Same author

Contraception during Coronavirus-Covid 19 pandemia. Recommendations of the Board of the Italian Society of Contraception.

The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception·2020
Same author

The Complexity of Dreams: a Multiscale Entropy Study on Cardiovascular Variability Series.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2020
Same author

The 2015 World Health Organization Classification of lung tumors: new entities since the 2004 Classification.

Pathologica·2018
Same author

Sofosbuvir in combination with daclatasvir or simeprevir for 12 weeks in noncirrhotic subjects chronically infected with hepatitis C virus genotype 1: a randomized clinical trial.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2018
Same journal

Treatment of scleral melt associated with uveal prolapse by pericardium grafting in Wegener's granulomatosis.

Metabolic, pediatric, and systemic ophthalmology (New York, N.Y. : 1985)·2002
Same journal

Optic nerve compression by extramedullary hematopoietic tissue in a patient suffering from beta-thalassemia intermedia.

Metabolic, pediatric, and systemic ophthalmology (New York, N.Y. : 1985)·2002
Same journal

Processing of animated contours by single cells in visual cortex area 18 of the cat.

Metabolic, pediatric, and systemic ophthalmology (New York, N.Y. : 1985)·2002
Same journal

Fluorescein angiography and indocyanine green videoangiography in the iris of pseudoexfoliation syndrome.

Metabolic, pediatric, and systemic ophthalmology (New York, N.Y. : 1985)·2001
Same journal

Anterior chamber hemorrhage during cataract surgery in Lowe syndrome.

Metabolic, pediatric, and systemic ophthalmology (New York, N.Y. : 1985)·2001
Same journal

A review of the role of visual problems in reading disabilities.

Metabolic, pediatric, and systemic ophthalmology (New York, N.Y. : 1985)·2001
See all related articles

Diabetes significantly impacts optic nerve health, causing lesions like gliosis and demyelination, particularly in long-term cases. Vascular damage in the optic nerve is a key factor in diabetic complications.

Area of Science:

  • Ophthalmology
  • Neuropathology
  • Endocrinology

Background:

  • Diabetes mellitus is a systemic disease with known ocular complications.
  • Optic nerve pathology in diabetes is not fully understood.
  • Vascular changes are implicated in diabetic microvascular disease.

Purpose of the Study:

  • To investigate the morphologic changes in the optic nerve of diabetic subjects.
  • To identify specific lesions and their association with diabetes duration.
  • To explore the role of vascular damage in diabetic optic neuropathy.

Main Methods:

  • Morphologic study of autoptic optic nerve material.
  • Inclusion of 80 diabetic subjects.
  • Comparison with an age-sex-matched control group of non-diabetic subjects.

Related Experiment Videos

Main Results:

  • Gliosis (19 cases) and demyelination (18 cases) were the most frequent lesions in diabetic optic nerves, associated with longer diabetes history.
  • Other observed lesions included focal infarctions, atrophy, and diverse vascular changes affecting microcirculation (thickening, hyalinosis, microaneurysms, thromboses).
  • Control group showed no significant similar lesions, highlighting diabetes-specific pathology.

Conclusions:

  • Diabetes mellitus is a significant factor in the development of optic nerve pathological changes.
  • Marked vascular damage, potentially from early-onset diabetes, is suggested as a key pathogenetic factor.
  • Diabetic optic neuropathy involves a spectrum of degenerative and vascular lesions.