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Application of neurally adjusted ventilatory assist in ventilator weaning of infants ventilator weaning

Shuna Xiao1, Chengjiao Huang1, Ying Cheng1

  • 1Department of Pediatric Critical Medicine, Maternal and Child Health Care Hospital of Hubei Province, Wuhan, China.

Brain and Behavior
|September 14, 2021
PubMed

Insights

Neurally adjusted ventilatory assist (NAVA) improves infant ventilator weaning by enhancing patient coordination and reducing peak inspiratory pressure. This method shows better therapeutic effects and positive application value for ventilator withdrawal.

Area of Science:

  • Pediatric Critical Care
  • Respiratory Physiology
  • Mechanical Ventilation

Background:

  • Infant mechanical ventilation is crucial for respiratory support.
  • Ventilator weaning is a critical step in infant respiratory care.
  • Neurally adjusted ventilatory assist (NAVA) offers a potential improvement over conventional methods.

Purpose of the Study:

  • To analyze the application and effectiveness of NAVA in ventilator weaning of infants.
  • To compare NAVA with continuous positive airway pressure (CPAP) during the weaning process.

Main Methods:

  • A study involving 25 infants in a pediatric intensive care unit (PICU).
  • Infants received both CPAP and NAVA mechanical ventilation before ventilator withdrawal.
  • Electrical activity of the diaphragm (EAdi) signals were monitored, and various respiratory and hemodynamic indexes were recorded.

Main Results:

  • NAVA mode resulted in lower peak inspiratory pressure (PIP) compared to CPAP (p < .05).
  • Significant differences were observed in peak pressure, mean pressure, compliance, and mean arterial pressure between CPAP and NAVA in 23 patients (p < .01).
  • Hemodynamic and PaCO2 indexes showed no significant differences between the two modes.

Conclusions:

  • NAVA significantly improves patient-ventilator coordination.
  • NAVA demonstrates better therapeutic effects, benefiting patient prognosis.
  • NAVA has positive application value in facilitating ventilator withdrawal in infants.
Abstract

Keywords:
continuous positive airway pressureinfantsneurally adjusted ventilatory assistvalue and applicationventilator weaning

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