Related Experiment Video

Updated: Oct 20, 2025

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
10:36

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer

Published on: March 17, 2016

10.7K

Non-genomic signaling of steroid receptors in cancer

Charlène Thiebaut1, Virginie Vlaeminck-Guillem2, Olivier Trédan3

  • 1Université de Lyon, F-69000, Lyon, France; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, F-69000, Lyon, France; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, F-69000, Lyon, France.

Molecular and Cellular Endocrinology
|September 14, 2021
PubMed

Insights

Steroid receptors (SRs) control cellular functions and cancer. This review details non-genomic signaling pathways of SRs in breast and prostate cancers, offering insights for new therapeutic strategies.

Area of Science:

  • Molecular Biology
  • Endocrinology
  • Oncology

Background:

  • Steroid receptors (SRs) are nuclear receptors regulating physiological functions and pathologies like cancer.
  • Cellular responses to steroids involve genomic and non-genomic activities.
  • Non-genomic signaling is crucial in breast (ER, PR) and prostate (AR) cancers.

Purpose of the Study:

  • To review current and emerging knowledge on non-genomic SR signaling.
  • To focus on breast and prostate cancers and their clinical relevance.
  • To explore potential therapeutic strategies based on non-genomic pathways.

Main Methods:

  • Literature review of studies on non-genomic steroid receptor signaling.
  • Focus on in vitro and in vivo evidence.
  • Analysis of clinical relevance in breast and prostate cancers.

Main Results:

  • Non-genomic signaling plays a significant role in cancer development and progression.
  • Specific SRs (ER, PR, AR) exhibit distinct non-genomic activities in relevant cancers.
  • Studies confirm the relevance of these pathways both in vitro and in vivo.

Conclusions:

  • Understanding non-genomic SR pathways is vital for cancer research.
  • Targeting non-genomic signaling offers novel therapeutic opportunities.
  • Further research into ER, PR, AR, and GR non-genomic pathways may lead to improved cancer treatments.
Keywords:
Androgen receptorERα36Estrogen receptorGlucocorticoid receptorNon-genomic signalingProgesterone receptor

More Related Videos

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists10:51

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Published on: November 15, 2013

12.9K
Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment11:13

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Published on: June 9, 2023

1.8K

Related Concept Videos

Transducer Mechanism: Nuclear Receptors01:31

Transducer Mechanism: Nuclear Receptors

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
1.9K
Signal Transduction: Overview01:26

Signal Transduction: Overview

Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
9.9K
Internal Receptors01:31

Internal Receptors

Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
72.0K
Chemical Signaling in the Endocrine System01:08

Chemical Signaling in the Endocrine System

A signaling cascade is a series of events that facilitates the transmission of information within or between cells, culminating in a targeted response in the recipient cell. As chemical messengers, hormones are pivotal in initiating and modulating these intricate signaling cascades based on their solubility.
Lipid-soluble hormones, such as steroid hormones, demonstrate an intracellular action. These hormones traverse cell membranes due to their lipid nature. Once inside the target cell, they...
4.4K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.9K
Autocrine Signaling01:01

Autocrine Signaling

Autocrine signaling is one of the many signaling mechanisms that function inside multicellular organisms to carry out intercellular communication. In this type of signaling mechanism, the same cell that secretes an extracellular signaling molecule also expresses the receptors to bind and respond to that signaling molecule.
Autocrine Signaling in Macrophages
Under normal physiological conditions, autocrine signaling is essential for maintaining homeostasis. This process is well characterized in...
49.4K