Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Crossing Over01:30

Crossing Over

5.0K
Crossing over is the exchange of genetic information between homologous chromosomes during prophase I of meiosis I. Genetic recombination gives rise to allelic diversity in the newly formed daughter cells. In humans, crossing over produces genetically distinct haploid egg and sperm cells that undergo fertilization to produce unique offspring. Before cell division starts, the germ cell’s chromosome(s) undergo duplication in the S phase of the cell cycle. As the cells enter prophase I,...
5.0K
Conservative Site-specific Recombination and Phase Variation02:53

Conservative Site-specific Recombination and Phase Variation

6.3K
Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
6.3K
Exon Recombination02:32

Exon Recombination

3.8K
The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon...
3.8K
Gene Conversion02:08

Gene Conversion

10.1K
Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
10.1K
Overview of Transposition and Recombination02:13

Overview of Transposition and Recombination

16.6K
Transposons make up a significant part of genomes of various organisms. Therefore, it is believed that transposition played a major evolutionary role in speciation by changing genome sizes and modifying gene expression patterns. For example, in bacteria, transposition can lead to conferring antibiotic resistance. Movement of transposable elements within the genetic pool of pathogenic bacteria can aid in transfer of antibiotic-resistant genetic elements. In eukaryotes, transposons can carry out...
16.6K
Homologous Recombination02:31

Homologous Recombination

55.9K
The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One of these sequences uses a strand from another as a template to synthesize DNA in an enzyme-catalyzed reaction. The final product is a novel amalgamation of the two substrates. To ensure an accurate recombination of sequences, HR is restricted to the S and G2 phases of the cell cycle. At these stages, the DNA has been replicated already and the...
55.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Detection of previously undiagnosed conditions in midlife preventive health examinations.

Scientific reports·2026
Same author

Sample Size Recalculation in Adaptive Group Sequential Study Designs for Comparing Restricted Mean Survival Times.

Statistics in medicine·2026
Same author

Multiple linear regression modeling with values below a lower limit of quantification - a statistical method comparison.

BMC medical research methodology·2026
Same author

Beyond Bonferroni: new multiple contrast tests for time-to-event data under non-proportional hazards.

Lifetime data analysis·2026
Same author

Evolving genealogies in cultural evolution, the descendant process, and the number of cultural traits.

Theoretical population biology·2025
Same author

The general health status of employees in Germany aged 45 to 59 years (Ü45-Check) - a cross-sectional study.

BMC public health·2025
Same journal

Applying invasion criterion to cultural evolution.

Theoretical population biology·2026
Same journal

The joint spectrum over trees under the Kingman coalescent with varying population.

Theoretical population biology·2026
Same journal

Statistical test to compare the linkage model and the admixture model based on central limit results.

Theoretical population biology·2026
Same journal

Threshold dynamics in age-structured distributions with expanding support: A unified mathematical framework.

Theoretical population biology·2026
Same journal

Mechanistic-statistical model for the expansion of ash dieback.

Theoretical population biology·2026
Same journal

Dynamics of an intraguild predation system with optimal foraging and harvesting.

Theoretical population biology·2026
See all related articles

Related Experiment Video

Updated: Oct 20, 2025

Recombineering Homologous Recombination Constructs in Drosophila
14:23

Recombineering Homologous Recombination Constructs in Drosophila

Published on: July 13, 2013

19.5K

Selection, recombination, and the ancestral initiation graph.

Frederic Alberti1, Carolin Herrmann2, Ellen Baake1

  • 1Faculty of Technology, Bielefeld University, Postbox 100131, 33501 Bielefeld, Germany.

Theoretical Population Biology
|September 14, 2021
PubMed
Summary
This summary is machine-generated.

We introduce the ancestral initiation graph, a simpler method to analyze selection and recombination. This new approach clarifies how the position of a selected gene affects linked neutral genes.

Keywords:
Ancestral initiation graphHitchhikingLinkage disequilibriumPopulation geneticsSelection–recombination differential equation

More Related Videos

Subcloning Plus Insertion SPI - A Novel Recombineering Method for the Rapid Construction of Gene Targeting Vectors
09:02

Subcloning Plus Insertion SPI - A Novel Recombineering Method for the Rapid Construction of Gene Targeting Vectors

Published on: January 8, 2015

16.7K
Molecular Evolution of the Tre Recombinase
12:02

Molecular Evolution of the Tre Recombinase

Published on: May 29, 2008

9.9K

Related Experiment Videos

Last Updated: Oct 20, 2025

Recombineering Homologous Recombination Constructs in Drosophila
14:23

Recombineering Homologous Recombination Constructs in Drosophila

Published on: July 13, 2013

19.5K
Subcloning Plus Insertion SPI - A Novel Recombineering Method for the Rapid Construction of Gene Targeting Vectors
09:02

Subcloning Plus Insertion SPI - A Novel Recombineering Method for the Rapid Construction of Gene Targeting Vectors

Published on: January 8, 2015

16.7K
Molecular Evolution of the Tre Recombinase
12:02

Molecular Evolution of the Tre Recombinase

Published on: May 29, 2008

9.9K

Area of Science:

  • Population genetics
  • Mathematical biology
  • Evolutionary dynamics

Background:

  • The selection-recombination equation models genetic changes.
  • Previous methods, like the ancestral selection-recombination graph, were complex.
  • Understanding linkage disequilibrium dynamics is crucial in population genetics.

Purpose of the Study:

  • Introduce a more accessible method, the ancestral initiation graph.
  • Explain the dynamics of linkage disequilibrium.
  • Clarify the influence of selected site position on neutral loci.

Main Methods:

  • Discretization of the selection-recombination equation.
  • Construction of the ancestral initiation graph.
  • Application to analyze hitchhiking effects.

Main Results:

  • The ancestral initiation graph provides a simplified analysis.
  • The method systematically explains long-standing observations on linkage disequilibrium.
  • The dependence of linkage disequilibrium on selected site position is clarified.

Conclusions:

  • The ancestral initiation graph is a valuable tool for population genetics research.
  • This method enhances understanding of genetic drift and selection interactions.
  • It offers new insights into the evolution of linked genetic sites.