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Related Experiment Video

Updated: Oct 20, 2025

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Developmentally regulated GTP-binding protein-2 regulates adipocyte differentiation.

Byong Seo Park1, Hye Li Im2, Nal Ae Yoon2

  • 1Department of Biological Science, University of Ulsan, Ulsan, 44610, South Korea; Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, 22012, South Korea.

Biochemical and Biophysical Research Communications
|September 14, 2021
PubMed
Summary

Developmentally regulated GTP-binding protein 2 (DRG2) promotes adipocyte differentiation and lipid metabolism, contributing to obesity. Overexpression of DRG2 in mice led to increased body weight and adiposity.

Keywords:
AdipogenesisDevelopmentally regulated GTP-Binding protein 2 (DRG2)Lipid metabolismObesityPeroxisome proliferator activated receptor-γ (PPAR-γ)

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Area of Science:

  • Molecular Biology
  • Metabolic Research
  • Obesity Studies

Background:

  • Developmentally regulated GTP-binding protein 2 (DRG2) is known to regulate cell proliferation and differentiation.
  • The specific role of DRG2 in adipocyte differentiation and metabolic control has not been fully elucidated.

Purpose of the Study:

  • To investigate the role of DRG2 in adipocyte differentiation.
  • To determine the impact of DRG2 on metabolic control and obesity development.

Main Methods:

  • Generation and analysis of DRG2 transgenic (Tg) mice.
  • Assessment of body weight, adiposity, and gene expression in white adipose tissue.
  • In vitro studies using cultured adipocytes to examine DRG2's interaction with PPAR-γ.

Main Results:

  • DRG2 Tg mice exhibited increased body weight and adiposity.
  • Gene expression analysis revealed upregulation of adipogenesis and lipid metabolism genes in DRG2 Tg mice.
  • DRG2 was found to promote adipogenesis by cooperating with peroxisome proliferator activated receptor-γ (PPAR-γ).

Conclusions:

  • DRG2 plays a significant role in regulating adipocyte differentiation.
  • DRG2 contributes to the development of obesity, particularly under a high-fat diet.
  • Targeting DRG2 may offer a potential strategy for managing obesity.