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Mesenchymal stem cells: A comprehensive methods for odontoblastic induction.

Benson Koh1, Nadiah Sulaiman1, Sharifah Nursyazwani Shahirah Wan Ismadi1

  • 1Centre for Tissue Engineering & Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, 56000, Cheras, Kuala Lumpur, Malaysia.

Biological Procedures Online
|September 15, 2021
PubMed
Summary
This summary is machine-generated.

Scaffold-based methods show promise for inducing odontoblastic differentiation, potentially enhancing pulp tissue regeneration in dentistry. Further research is needed to optimize these techniques.

Keywords:
Dental cellsDentinogenesisMesenchymal stem cellsOdontoblastic differentiation

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Endodontics

Background:

  • Regenerative endodontics offers alternatives to conventional treatments in oral surgery.
  • Cell sources for pulp regeneration extend beyond mesenchymal stem cells to include non-mesenchymal stem cells.
  • This review systematically assesses recent findings on odontoblastic differentiation induction.

Purpose of the Study:

  • To systematically review and assess recent findings on odontoblastic differentiation induction.
  • To compare scaffold-based and non-scaffold approaches for odontoblastic differentiation.
  • To identify potential enhancements for pulp tissue regeneration.

Main Methods:

  • A comprehensive literature search was conducted in PubMed and Scopus (2015-2020).
  • Studies focused on in vitro methods for odontoblast differentiation, excluding in vivo and clinical research.
  • Inclusion criteria required articles to contain "odontoblast", "differentiation", and "mesenchymal stem cell".

Main Results:

  • Eleven studies met the inclusion criteria from 99 initial results.
  • Five studies utilized scaffold-based induction, while six used non-scaffold methods.
  • Data categorized cell types and differentiation techniques (scaffold vs. non-scaffold).

Conclusions:

  • Scaffold-based odontoblastic induction appears superior to non-scaffold methods.
  • Growth factor combinations may enhance differentiation in scaffold-based approaches.
  • Further research is required to elucidate mechanisms and optimize odontoblastic differentiation.