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COVID-19 in Pregnancy and Early Childhood (COPE): study protocol for a prospective, multicentre biobank, survey and

Ylva Carlsson1,2, Lina Bergman1,2, Mehreen Zaigham3,4

  • 1Department of Obstetrics and Gynaecologyhe, Institute of Clinical Science, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

BMJ Open
|September 15, 2021
PubMed

Insights

This study examines the impact of SARS-CoV-2 (COVID-19) on pregnancy outcomes and long-term maternal and child health. It establishes a biobank and database to track health and parental experiences during the pandemic.

Area of Science:

  • Obstetrics and Gynecology
  • Infectious Diseases
  • Public Health
  • Epidemiology

Background:

  • Limited knowledge exists on SARS-CoV-2 effects on pregnancy outcomes.
  • Studies on COVID-19's impact in early pregnancy and long-term follow-up are scarce.
  • Understanding pandemic effects on maternal and child health is crucial.

Purpose of the Study:

  • To investigate the impact of COVID-19 on pregnancy outcomes.
  • To assess long-term maternal and child health following SARS-CoV-2 infection during pregnancy.
  • To examine parental experiences of pregnancy, childbirth, and early parenthood during the COVID-19 pandemic.

Main Methods:

  • Prospective, multicentre cohort study in Sweden involving over 86,000 deliveries annually.
  • Inclusion of pregnant women who test positive for SARS-CoV-2 (COVID-19 group) or are non-infected (screening group).
  • Collection of biological samples, health data from registers, and parental experiences via questionnaires and interviews.

Main Results:

  • Data collection ongoing; results to be published in peer-reviewed journals.
  • Establishment of a comprehensive database and biobank for pregnant women and infants.
  • Analysis of short- and long-term health outcomes and parental experiences.

Conclusions:

  • The study will provide crucial insights into the effects of COVID-19 on pregnancy and long-term health.
  • Findings will inform clinical practice and public health strategies related to infectious diseases in pregnancy.
  • The research addresses a significant gap in understanding the pandemic's impact on families.
Abstract

Keywords:
COVID-19epidemiologyneonatologyobstetrics

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