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Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons
Revathy Munuswamy1, Jana De Brandt2, Chris Burtin2
1Faculty of Medicine and Life Sciences, Biomedical Research Institute BIOMED, Hasselt University, Hasselt, Belgium.
Journal of Inflammation Research
|September 15, 2021
Summary
Monomeric C-reactive protein (mCRP) is a more sensitive biomarker for chronic low-grade systemic inflammation in chronic obstructive pulmonary disease (COPD) patients. Elevated mCRP levels were observed in COPD patients compared to controls.
Area of Science:
- Pulmonary Medicine
- Immunology
- Biomarker Discovery
Background:
- Chronic low-grade systemic inflammation is a hallmark of Chronic Obstructive Pulmonary Disease (COPD).
- Pentameric C-reactive protein (pCRP) has anti-inflammatory properties, but can dissociate into pro-inflammatory monomeric C-reactive protein (mCRP).
Purpose of the Study:
- To investigate the potential of monomeric C-reactive protein (mCRP) as a sensitive biomarker for chronic low-grade systemic inflammation in COPD.
- To compare mCRP levels in patients with COPD versus non-COPD controls.
Main Methods:
- Serum samples were collected from 38 patients with COPD and 18 non-COPD control persons (NCCP).
- Levels of monomeric C-reactive protein (mCRP) were analyzed in all serum samples.
Main Results:
- Monomeric C-reactive protein (mCRP) levels were significantly elevated in patients with COPD compared to non-COPD controls (NCCP).
- This finding supports the pro-inflammatory role of mCRP in the context of COPD.
Conclusions:
- Monomeric C-reactive protein (mCRP) may serve as a novel and sensitive biomarker for detecting chronic low-grade systemic inflammation in COPD.
- Further research into mCRP's role could offer new diagnostic and therapeutic insights for COPD management.
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