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Updated: Oct 20, 2025
Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis
Published on: November 26, 2015
JPX and LINC00641 ncRNAs expression in prostate tissue: a case-control study
Roshanak S Sajjadi1, Mohammad Hossein Modarressi2, Mohammad Amin Tabatabaiefar1,3
1Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
Background And Purpose:
Prostate cancer (PC) is the second most prevalent cancer in men. Prostate-specific antigen (PSA) is the main biomarker for screening PC. An increase in PSA could lead to false-positive results. Thus, more appropriate markers should be investigated. In the present study, JPX and LINC00641 expression levels were measured in tumoral prostate tissue compared with the non-tumor tissue.
Experimental Approach:
43 pairs of prostate tumoral and non-tumor tissue were prepared. The expression levels of JPX and LINC00641 were investigated by RT-qPCR.
Findings/Results:
Significant upregulation of LINC00641 (2.47 ± 0.5 vs 1.41 ± 0.2) and downregulation of JPX (1.42 ± 0.6 vs 2.83 ± 1.0) were observed in PC tissues compared with the normal tissues (their adjacent non-tumoral tissues).
Conclusion And Implications:
Dysregulation of JPX and LINC00641 in PC patients could be used in the future as a prognostic biomarker in PC.
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