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Updated: Oct 20, 2025

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1
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An Infant With Seborrhoeic Dermatitis and Eczema Herpeticum Complicated by a Generalized Infection

Katarzyna Karpierz1, Ernest P Kuchar1

  • 1Pediatrics with Clinical Assessment Unit, Medical University of Warsaw, Warsaw, POL.

Cureus
|September 15, 2021
PubMed

Insights

Primary herpes simplex virus 1 (HSV-1) infection can cause severe illness in children, particularly those with skin conditions like eczema. Early diagnosis and acyclovir treatment are crucial for managing symptoms and preventing complications.

Area of Science:

  • Pediatrics
  • Dermatology
  • Infectious Diseases

Background:

  • Primary herpes simplex virus 1 (HSV-1) infections in children can range from asymptomatic to severe, life-threatening conditions.
  • At-risk children, especially those with atopic dermatitis, are susceptible to extensive eczema herpeticum (eruptio varicelliformis Kaposi).
  • Severe manifestations include herpes simplex eye infection, encephalitis, and disseminated herpes infection.

Observation:

  • A case study involving a boy with exacerbated infantile seborrhoeic dermatitis (ISD) and eczema herpeticum complicated by streptococcal sepsis is presented.
  • This highlights the potential for severe secondary bacterial infections in children with compromised skin barriers and HSV-1.

Findings:

  • HSV-1 infection in children can lead to severe complications, including eczema herpeticum and secondary sepsis.
  • Prompt initiation of acyclovir therapy can reduce the duration of symptoms.
  • Preventive measures, including educating parents on skin care and recognizing "red flag" symptoms, are vital.

Implications:

  • Emphasizes the importance of recognizing severe HSV-1 manifestations in pediatric patients with underlying skin conditions.
  • Highlights the need for parental education regarding skin barrier function and early medical consultation for concerning symptoms.
  • Underscores the role of antiviral therapy in mitigating HSV-1 related illness severity in children.

Keywords:
bacterial superinfectionid critical careintenssive careinvasive infectionkidslife-threatening sequellaelocal therapyrisk factorsskin disease/ dermatology

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