Contemporary biomedical engineering perspective on volitional evolution for human radiotolerance enhancement beyond...

Area of Science:

• Astrobiology
• Genetics
• Biotechnology

Background:

• Human space exploration beyond low-Earth orbit presents significant risks from ionizing radiation.
• Current physiological defenses are insufficient for long-term interplanetary missions.
• Pathologies from space radiation exposure require thorough characterization and mitigation strategies.

Purpose of the Study:

• To explore volitional evolution as a pragmatic approach to mitigate space radiation pathologies.
• To investigate the potential of uniquely radioprotective genes and gene-editing technologies for enhancing human radiotolerance.
• To consider ethical implications and complementary strategies for radiation protection in space.

Main Methods:

• Identification of uniquely radioprotective genes.
• Application of CRISPR/Cas9 for targeted genomic modifications.
• Computational modeling of biological networks through artificial intelligence and genetic engineering.

Main Results:

• Certain genes confer radiotolerance when overexpressed in vitro and in vivo.
• CRISPR/Cas9 offers a reproducible method for precise genomic alterations.
• Advanced propulsion and synthetic torpor are identified as complementary strategies.

Conclusions:

• Volitional evolution, guided by genetic engineering, presents a viable path for human adaptation to space radiation.
• Ethical considerations are paramount when introducing genetically modified humans for space exploration.
• A multi-faceted approach combining genetic engineering, advanced technology, and computational modeling is essential for future deep space missions.