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Experimentally induced lactic acidosis in the goat
G R Cao1, P B English, L J Filippich
1Department of Veterinary Medicine, University of Queensland, St Lucia.
Australian Veterinary Journal
|December 1, 1987
Summary
Experimental lactic acidosis in goats, induced by oral sucrose, was preceded by metabolic alkalosis. Treatment with calcium hydroxide and bicarbonate aimed to correct the induced metabolic disturbance.
Area of Science:
- Veterinary Medicine
- Animal Physiology
- Biochemistry
Background:
- Lactic acidosis is a critical metabolic condition.
- Understanding its induction and progression in ruminants is vital for animal health.
- Sucrose overconsumption can disrupt normal rumen function.
Purpose of the Study:
- To experimentally induce lactic acidosis in goats using sucrose.
- To monitor the biochemical and physiological changes during induced lactic acidosis.
- To evaluate the efficacy of calcium hydroxide and bicarbonate treatment.
Main Methods:
- Lactic acidosis was induced twice in 4 adult female goats via oral sucrose (18 g/kg).
- Ruminal fluid, plasma, and blood were analyzed for pH, osmolality, and lactic acid over 48 hours.
- Urinary pH and sediment were also examined.
- Treatment with calcium hydroxide and bicarbonate was administered post-24 hours.
Main Results:
- Experimental induction of lactic acidosis was achieved.
- Significant changes in ruminal fluid, plasma, and blood parameters were observed.
- A preceding metabolic alkalosis was a notable feature in the goats.
- Treatment was initiated to manage the metabolic disturbance.
Conclusions:
- Oral sucrose administration effectively induces lactic acidosis in goats.
- The study highlights a unique preceding metabolic alkalosis in this model.
- Calcium hydroxide and bicarbonate show potential for ameliorating the induced metabolic disturbance.