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Updated: Oct 20, 2025

Proton Transfer and Protein Conformation Dynamics in Photosensitive Proteins by Time-resolved Step-scan Fourier-transform Infrared Spectroscopy
Published on: June 27, 2014
Multiscale conformational dynamics probed by time-resolved circular dichroism from seconds to picoseconds
François Hache1, Pascale Changenet1
1Optics and Biosciences Laboratory, CNRS, INSERM, Ecole Polytechnique, Institut Polytechnique de Paris, Palaiseau, France.
Abstract:
Time-resolved circular dichroism has been developed for a few decades to investigate rapid conformational changes in (bio)molecules. In our group, we have come up with several experimental set-ups allowing us to study pico-nanosecond local phenomena in molecular systems as well as much slower effects occurring in proteins and DNA in the folding processes. After an overview of the worldwide realizations in this domain, we present emblematic experiments that we have carried out, spanning time domain from picoseconds to seconds.
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