Left ventricular long-axis ultrasound strain (GLS) is an ideal indicator for patients with anti-hypertension...

Area of Science:

• Cardiology
• Cardiovascular Imaging
• Hypertension Research

Background:

• Primary hypertension is a major cardiovascular disease risk factor.
• Current indicators for left ventricular end-diastolic pressure are suboptimal.
• Novel markers are needed for effective hypertension management.

Purpose of the Study:

• To evaluate Global Longitudinal Strain (GLS) as a potential indicator for left ventricular end-diastolic pressure in hypertension.
• To assess the efficacy of antihypertensive treatment using echocardiographic parameters, including GLS.
• To compare the treatment response of GLS with other diastolic function indices.

Main Methods:

• Echocardiography was performed on 73 hypertensive patients and 37 controls.
• Key parameters measured included Peak mitral valve flow velocity (E, A), E/A, left atrial volume index (LAVl), tissue Doppler (PW-TDI) peak velocities (e'), E/e', and GLS.
• Measurements were taken before, one month, and three months after antihypertensive treatment.

Main Results:

• Left ventricular end-diastolic pressure (LVEDP) correlated positively with GLS and negatively with E/e'.
• Hypertensive patients exhibited lower e' and higher GLS, E/e', and LAVI compared to controls.
• GLS and E/e' improved significantly after treatment, with GLS showing a superior improvement rate.

Conclusions:

• Global Longitudinal Strain (GLS) demonstrated a significantly higher improvement rate than e' and E/e' after one and three months of antihypertensive treatment.
• GLS may serve as a potential ideal index for monitoring patients undergoing antihypertensive therapy.
• These findings offer valuable insights for future research in hypertension management.