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Isolated diastolic hypertension and target organ damage: Findings from the STANISLAS cohort

Luca Monzo1,2, João Pedro Ferreira1, Zohra Lamiral1

  • 1Université de Lorraine, Inserm, Centre d'Investigations Cliniques, - Plurithématique 14-33, and Inserm U1116, CHRU Nancy, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France.

Clinical Cardiology
|September 15, 2021
PubMed

Insights

Isolated diastolic hypertension (IDH) did not show significant links to target organ damage in a large cohort study. Further research is needed to understand the clinical significance of IDH in cardiovascular risk assessment.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Clinical Epidemiology

Background:

  • Isolated diastolic hypertension (IDH) is defined by the 2017 ACC/AHA guidelines as diastolic blood pressure (DBP) ≥80 mmHg and systolic blood pressure (SBP) <130 mmHg.
  • The association between IDH and cardiovascular risk, particularly target organ damage (TOD), remains a subject of debate.

Purpose of the Study:

  • To investigate the potential contribution of IDH to the development of hypertension-related target organ damage (TOD).

Main Methods:

  • A cross-sectional analysis of 1605 subjects from the STANISLAS cohort was conducted.
  • Participants were categorized into normal BP, combined hypertension, IDH, and isolated systolic hypertension (ISH) groups based on 24-h ambulatory blood pressure monitoring.
  • Multivariable-adjusted logistic models assessed the association between hypertension status and various markers of TOD.

Main Results:

  • IDH was not significantly associated with elevated NTproBNP, microalbuminuria, diastolic dysfunction, increased left ventricular (LV) mass index, altered LV longitudinal strain, increased carotid intima-media thickness, reduced ankle-brachial index, or elevated pulse wave velocity (PWV) compared to normotension.
  • In contrast, combined hypertension and ISH were independently associated with increased LV mass index and PWV.

Conclusions:

  • The study found no significant association between Isolated Diastolic Hypertension and target organ damage.
  • Further research is required to fully elucidate the clinical implications and role of IDH in cardiovascular health.
Abstract

Keywords:
ambulatory blood pressureisolated diastolic hypertensiontarget organ damage

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