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Efficacy of Statin Therapy in Patients with Hospital Admission for COVID-19

Daein Choi1, Qinzhong Chen2, Sascha N Goonewardena3

  • 1Department of Medicine, Mount Sinai Beth Israel, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Cardiovascular Drugs and Therapy
|September 15, 2021
PubMed

Insights

Statin use in hospitalized COVID-19 patients was linked to lower in-hospital death rates. This protective effect was more pronounced in patients with coronary artery disease, suggesting continued statin therapy is beneficial.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Pharmacology

Background:

  • COVID-19 involves immune dysfunction and metabolic issues, potentially leading to organ failure.
  • Statins, used for cardiovascular disease, have immune-modulating effects.
  • The potential benefit of statins in COVID-19 warrants investigation.

Purpose of the Study:

  • To investigate the association between statin use and mortality in patients hospitalized with COVID-19.

Main Methods:

  • Analysis of 5,375 COVID-19 patients hospitalized between February 2020 and December 2020.
  • Classification of statin use: non-user, low-to-moderate-intensity, or high-intensity.
  • Multivariate Cox proportional hazards models adjusted for age, sex, race, and comorbidities.

Main Results:

  • Both low-to-moderate-intensity and high-intensity statin use were associated with reduced in-hospital mortality compared to non-users.
  • Adjusted hazard ratios (aHR) for mortality were 0.62 (95% CI 0.51-0.76) and 0.53 (95% CI 0.43-0.65), respectively.
  • In a subgroup of 723 coronary artery disease patients, high-intensity statin use showed a significant reduction in mortality (aHR 0.51, 95% CI 0.36-0.71).

Conclusions:

  • Statin use in hospitalized COVID-19 patients is associated with decreased in-hospital mortality.
  • The protective effect of statins appears greater in patients with coronary artery disease.
  • Continued statin therapy is supported for hospitalized COVID-19 patients, with clinical trials recommended to confirm efficacy.
Abstract

Keywords:
COVID-19Coronary artery diseaseMortalityStatin

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