Amyloid beta emerges from below the neck to disable the brain

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Updated: Oct 20, 2025

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Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus

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Grant Kauwe1, Tara E Tracy1

  • 1Buck Institute for Research on Aging, Novato, California, United States of America.

Plos Biology
|September 15, 2021
PubMed

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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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