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SPYing on triplet repeat expansions: Insights into FAN1-MLH1 interaction and regulation
1Centre for Chromosome Biology, National University of Ireland, Galway, Ireland; Galway Neuroscience Centre, National University of Ireland, Galway, Ireland.
Abstract:
The DNA repair proteins FAN1 and MLH1 have opposing effects on triplet repeat expansions. New studies by Goold et al. (2021) and Porro et al. (2021) pinpoint interactions between FAN1 and MLH1 that cross-regulate each other's activities.
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