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Association between body temperature and leukocyte telomere length in Korean middle-aged and older adults
Carolina García-García1, Chol Shin2, Inkyung Baik1
1Department of Foods and Nutrition, College of Natural Sciences, Kookmin University, Seoul, Korea.
Objectives:
Data on associations between body temperature (BT) and leukocyte telomere length (LTL), which has been widely used as a biomarker of cellular senescence in recent epidemiological studies, are limited. Therefore, this study aimed to explore the associations between a normal BT range (35.0-37.5°C) and LTL via 6-year longitudinal observations of 2,004 male and female adults aged 50 or older.
Methods:
BT was obtained by measuring the tympanic temperature, and relative LTL was determined by real-time polymerase chain reaction. Robust regression analysis was used to evaluate the association between the baseline and follow-up LTL values and their differences.
Results:
A significant inverse association was found between BT and LTL at baseline. The regression coefficient estimate was -0.03 (95% confidence interval, -0.07 to -0.001; p<0.05). This association was stronger in participants with a body mass index >25 kg/m2 and males (p<0.01). However, there were no associations between BT and LTL at follow-up or BT and 6-year longitudinal differences in LTL.
Conclusions:
These findings suggest that having a high BT between 35°C and 37.5°C (95°F and 99°F) may be detrimental for obese individuals in terms of biological aging.
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Step 2:
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Step 4:
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01:14Assessing Body Temperature - Tympanic membrane
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01:19Assessing Body Temperature - Temporal Artery
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