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Updated: Oct 20, 2025
Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
Published on: September 8, 2023
Murine femur micro-computed tomography and biomechanical datasets for an ovariectomy-induced osteoporosis model
Maialen Stephens1, Karen López-Linares1,2, Javier Aldazabal3
1Vicomtech Foundation, Donostia-San Sebastián, Spain.
Abstract:
The development of new effective and safer therapies for osteoporosis, in addition to improved diagnostic and prevention strategies, represents a serious need in the scientific community. Micro-CT image-based analyses in association with biomechanical testing have become pivotal tools in identifying osteoporosis in animal models by assessment of bone microarchitecture and resistance, as well as bone strength. Here, we describe a dataset of micro-CT scans and reconstructions of 15 whole femurs and biomechanical tests on contralateral femurs from C57BL/6JOlaHsd ovariectomized (OVX), resembling human post-menopausal osteoporosis, and sham operated (sham) female mice. Data provided for each mouse include: the acquisition images (.tiff), the reconstructed images (.bmp) and an.xls file containing the maximum attenuations for each reconstructed image. Biomechanical data include an.xls file with the recorded load-displacement, a movie with the filmed test and an.xls file collecting all biomechanical results.
Insights
This study presents a micro-computed tomography (micro-CT) and biomechanical dataset from ovariectomized (OVX) mice, offering valuable resources for osteoporosis research and therapeutic development.
Area of Science:
- Biomedical Engineering
- Orthopedics
- Radiology
Background:
- Osteoporosis necessitates novel therapies and diagnostic tools.
- Micro-CT imaging and biomechanical testing are crucial for assessing bone health in animal models.
- Current research requires comprehensive datasets for validating osteoporosis models.
Purpose of the Study:
- To provide a detailed dataset of micro-CT scans and biomechanical test results.
- To facilitate research on osteoporosis using a well-characterized mouse model.
- To support the development of new osteoporosis treatments and diagnostic strategies.
Main Methods:
- Acquisition and reconstruction of micro-CT scans from 15 whole mouse femurs.
- Biomechanical testing of contralateral femurs from ovariectomized (OVX) and sham-operated mice.
- Data compilation including image files, attenuation values, load-displacement curves, and biomechanical results.
Main Results:
- A comprehensive dataset comprising micro-CT images and biomechanical data was generated.
- The dataset includes raw and reconstructed images, attenuation data, and detailed biomechanical outcomes.
- This resource enables in-depth analysis of bone microarchitecture and mechanical properties.
Conclusions:
- The presented dataset serves as a valuable resource for osteoporosis research.
- It supports the investigation of bone changes and the efficacy of potential therapies.
- This data aids in advancing diagnostic and prevention strategies for osteoporosis.
