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Related Concept Videos

Phases of Wound Repair01:28

Phases of Wound Repair

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Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
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Overview of Regeneration and Repair01:19

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Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
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Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

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The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
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Related Experiment Video

Updated: Oct 20, 2025

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
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Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

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Wound Healing: A Comprehensive Review.

Yasser H Almadani1, Joshua Vorstenbosch1, Peter G Davison1

  • 1Division of Plastic Surgery, McGill University, Montreal, Quebec, Canada.

Seminars in Plastic Surgery
|September 16, 2021
PubMed
Summary

Skin wound healing is a complex process vital for skin barrier function. This review covers cutaneous wound healing phases, noting that disruptions can lead to chronic wounds.

Keywords:
chronic woundsinflammationwound healing

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Area of Science:

  • Dermatology
  • Regenerative Medicine
  • Cell Biology

Background:

  • Cutaneous wound healing is essential for skin integrity and function.
  • This physiological process involves multiple, coordinated cellular and molecular events.
  • Numerous factors can impact the efficacy and timeline of wound repair.

Purpose of the Study:

  • To provide a comprehensive overview of the classical phases of cutaneous wound healing.
  • To highlight the regulatory mechanisms governing skin repair.
  • To discuss factors that can impede or alter the normal wound healing cascade.

Main Methods:

  • Literature review of classical wound healing phases.
  • Analysis of regulatory factors influencing skin repair.
  • Focus on cutaneous manifestations and disruptions.

Main Results:

  • Wound healing progresses through distinct, sequential phases (e.g., inflammation, proliferation, remodeling).
  • Each phase is orchestrated by specific cellular signaling pathways.
  • Deviations in any phase can result in delayed healing or chronic wound formation.

Conclusions:

  • Understanding the phases of cutaneous wound healing is crucial for clinical practice.
  • Identifying modifiable factors can optimize therapeutic strategies for wound management.
  • Further research into the molecular regulation of wound healing may reveal novel treatment targets.