Related Experiment Video

Updated: Oct 20, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

1.8K

Variation in pulmonary function tests among children with sickle cell anemia: a systematic review and meta-analysis

Amar Taksande1, Patel Zeeshan Jameel1, Divya Pujari2

  • 1Department of Paediatrics, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi Meghe, Wardha, Maharashtra State, India.

The Pan African Medical Journal
|September 16, 2021
PubMed

Insights

Children with sickle cell anemia (SCA) show reduced lung function, specifically lower forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC). Routine pulmonary function tests (PFTs) are recommended for early detection of lung decline in SCA patients.

Area of Science:

  • Pulmonary Medicine
  • Pediatrics
  • Hematology

Background:

  • Sickle cell anemia (SCA) is associated with various pulmonary complications, including acute chest syndrome (ACS), pulmonary hypertension (PH), and airway hyper-responsiveness (AHR).
  • Pulmonary function abnormalities are common in children with SCA, necessitating further investigation.

Purpose of the Study:

  • To examine pulmonary function test (PFT) abnormalities in children diagnosed with sickle cell anemia (SCA).
  • To assess the impact of SCA on lung function parameters in pediatric patients.

Main Methods:

  • A systematic review and meta-analysis of case-control studies was conducted.
  • Electronic databases (Cochrane library, PubMed, EMBASE, Scopus, Web of Science) were searched for relevant studies.
  • Pulmonary functions were assessed using spirometry, lung volume, and gas diffusion findings in 788 SCA children and 1101 controls.

Main Results:

  • Nine studies were analyzed, involving 788 children with SCA and 1101 controls.
  • Significant decreases were observed in forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) in children with SCA compared to controls.
  • Other assessed parameters like FEV1/FVC ratio, peak expiratory flow rate (PEFR), total lung capacity (TLC), and carbon monoxide diffusing capacity (DLCO) showed non-significant trends towards reduction.

Conclusions:

  • Sickle cell anemia is associated with significantly reduced FEV1 and FVC in children.
  • These findings support the importance of routine pulmonary function monitoring for early detection of lung function decline in pediatric SCA patients, particularly those with a history of ACS.
Abstract

Keywords:
Sickle cell anaemiapulmonary function testsspirometry

More Related Videos

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

10.0K
Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets08:08

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets

Published on: May 11, 2015

14.3K

Related Concept Videos

Pulmonary Function Tests01:25

Pulmonary Function Tests

Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
464
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
2.6K
Factors Affecting Pulmonary Ventilation01:19

Factors Affecting Pulmonary Ventilation

Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
1.9K
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
28
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
35
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
3.3K