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Correlation between serum miR-122 and myocardial damage and ventricular function in patients with essential
1Department of Cardiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Insights
Elevated serum miR-122 levels in essential hypertension (EH) patients correlate with increased myocardial damage markers and decreased ventricular function, specifically ejection fraction (EF) and isovolumic relaxation time (IVRT). This suggests miR-122 may indicate cardiac impairment in EH.
Area of Science:
- Cardiology
- Molecular Biology
- Biochemistry
Background:
- Essential hypertension (EH) is linked to myocardial damage and impaired ventricular function, negatively impacting prognosis.
- MicroRNAs are implicated in the pathophysiology of hypertensive heart disease.
- Investigating specific microRNAs like miR-122 can reveal mechanisms of cardiac dysfunction in EH.
Purpose of the Study:
- To determine the correlation between serum miR-122 levels and markers of myocardial damage.
- To assess the relationship between serum miR-122 and ventricular function indicators in EH patients.
Main Methods:
- Collected clinical data from 60 EH patients and 60 healthy controls.
- Measured serum miR-122, myocardial damage markers (BNP, Hcy, cTnT, CK-MB), and cardiac function indicators (EF, IVST, IVRT, LVEDD, LVPWT, LVESD).
- Analyzed correlations between serum miR-122 and the measured biomarkers and indicators.
Main Results:
- Serum miR-122 was significantly higher in EH patients (6.86±1.23 µmol/L) compared to controls (3.36±1.87 µmol/L).
- EH patients exhibited elevated levels of myocardial damage markers (BNP, Hcy, cTnT, CK-MB) and reduced ejection fraction (EF) and isovolumic relaxation time (IVRT).
- Serum miR-122 positively correlated with myocardial damage markers and negatively with EF and IVRT.
Conclusions:
- Serum miR-122 levels are elevated in EH patients.
- miR-122 concentration is positively associated with myocardial damage.
- miR-122 shows a negative correlation with ventricular function indicators EF and IVRT in EH.
Background:
Myocardial damage and decreased ventricular function are risk factors leading to a bad prognosis in patients with essential hypertension (EH). MicroRNAs play important roles in myocardial function impairment in patients with hypertension. The purpose of our research was to investigate the correlation between serum miR-122 and myocardial damage and ventricular functions in EH patients.
Methods:
The clinic data of EH patients (group A, n=60) and healthy individuals (group B, n=60) from December 2016 to December 2019 in our hospital were collected and analyzed. Serum miR-122, myocardial damage markers [B-type brain natriuretic peptide (BNP), homocysteine (Hcy), cardiac troponin T (cTnT) and creatine kinase MB isoenzyme (CK-MB)] and cardiac function indicators [ejection fraction (EF), left ventricular septal thickness (IVST), left ventricular isovolumic relaxation time (IVRT), left ventricular end-diastolic diameter (LVEDD), left ventricular posterior wall thickness (LVPWT), and left ventricular end-systolic diameter (LVESD)] were assessed in both groups. The correlation between serum miR-122 and myocardial damage markers and ventricular function indicators was analyzed.
Results:
(I) The mean serum miR-122 concentration in group A and group B was 6.86±1.23 and 3.36±1.87 µmol/L, respectively. The serum miR-122 concentration in group A was evidently increased compared with that in group B. (II) The levels of BNP, Hcy, cTnT, and CK-MB in the peripheral blood in group A were evidently increased compared with those in group B (P<0.05). (III) EF and IVRT were evidently decreased in group A compared with that in group B (P<0.05). (IV) Serum miR-122 concentration was positively correlated with the myocardial damage markers BNP, Hcy, cTnT and CK-MB, and serum miR-122 concentration was negatively correlated with the ventricular function indicators EF and IVRT but not significantly correlated with other ventricular function indicators (IVST, LVEDD, LVPWT and LVESD).
Conclusions:
The serum miR-122 concentration in EH patients was higher than that in healthy individuals, and miR-122 concentration was positively correlated with myocardial damage markers. Serum miR-122 level was negatively correlated with the ventricular function indicators EF and IVRT but was not significantly correlated with other ventricular function indicators (IVST, LVEDD, LVPWT, and LVESD).
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