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Targeting the Hippo pathway in heart repair
Fansen Meng1, Bing Xie1, James F Martin1,2
1Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Cardiovascular Research
|September 16, 2021
Summary
The Hippo pathway regulates organ size and is crucial for heart development and disease. Understanding its components, like LATS1/2 and YAP/TAZ, offers new therapeutic strategies for heart failure.
Area of Science:
- Cardiovascular Biology
- Cell Signaling
- Developmental Biology
Background:
- The Hippo pathway is a conserved signaling network controlling organ size through regulation of cell proliferation, apoptosis, and differentiation.
- The Hippo pathway plays significant roles in cardiac development, homeostasis, disease, and regeneration.
Purpose of the Study:
- To review the function of the Hippo pathway in the heart.
- To highlight post-translational modifications of Hippo pathway components and their downstream effectors (YAP/TAZ) in cardiac research.
Main Methods:
- Literature review focusing on Hippo pathway in cardiac contexts.
- Analysis of post-translational modifications of core kinases (LATS1/2) and effectors (YAP/TAZ).
Main Results:
- The Hippo pathway is integral to cardiac function and disease.
- Post-translational modifications of LATS1/2 and YAP/TAZ provide critical regulatory insights.
- These modifications influence cardiac development, homeostasis, and disease progression.
Conclusions:
- The Hippo pathway represents a promising therapeutic target for cardiovascular diseases, including heart failure.
- Further research into Hippo pathway modifications offers novel avenues for cardiac regenerative medicine.
