Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Defining neonatal encephalopathy: an international real-time Delphi consensus process.

The Lancet. Child & adolescent health·2026
Same author

Connecting families and science: a new model for participation in paediatric research.

Pediatric research·2026
Same author

Publisher Correction: Reporting pediatric randomized trials: why SPIRIT-C 2026 and CONSORT-C 2026 matter now.

Pediatric research·2026
Same author

Comparing extracellular vesicle enriched plasma proteomes between term and preterm neonates over the first days of life: post hoc analysis of a prospective observational study.

BMJ paediatrics open·2026
Same author

Reporting pediatric randomized trials: why SPIRIT-C 2026 and CONSORT-C 2026 matter now.

Pediatric research·2026
Same author

Cerebral Oximetry in Extremely Preterm Infants: 2-Year Follow-Up of the SafeBoosC-III Randomized Clinical Trial.

JAMA pediatrics·2026

Related Experiment Video

Updated: Oct 20, 2025

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

86.7K

Multi-organ dysfunction scoring in neonatal encephalopathy (MODE Score) and neurodevelopmental outcomes.

Deirdre Una Sweetman1,2, Tammy Strickland3, Eman Isweisi2,3

  • 1Neonatology, National Maternity Hospital, Dublin, Ireland.

Acta Paediatrica (Oslo, Norway : 1992)
|September 16, 2021
PubMed
Summary

A new scoring system, MODE, effectively quantifies multi-organ dysfunction in neonatal encephalopathy (NE). Higher MODE scores correlate with NE severity, mortality risk, and adverse neurodevelopmental outcomes, aiding early management.

Keywords:
multi-organ dysfunction scoreneonatal encephalopathy

More Related Videos

Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy
05:52

Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy

Published on: October 28, 2022

870
Application of an Amplitude-integrated EEG Monitor Cerebral Function Monitor to Neonates
05:58

Application of an Amplitude-integrated EEG Monitor Cerebral Function Monitor to Neonates

Published on: September 6, 2017

39.6K

Related Experiment Videos

Last Updated: Oct 20, 2025

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

86.7K
Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy
05:52

Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy

Published on: October 28, 2022

870
Application of an Amplitude-integrated EEG Monitor Cerebral Function Monitor to Neonates
05:58

Application of an Amplitude-integrated EEG Monitor Cerebral Function Monitor to Neonates

Published on: September 6, 2017

39.6K

Area of Science:

  • Neonatal Medicine
  • Pediatric Neurology
  • Critical Care

Background:

  • Neonatal encephalopathy (NE) poses a significant risk for multi-organ injury.
  • Standardized definitions for multi-organ dysfunction in NE are lacking, impeding accurate assessment.
  • Early identification of organ dysfunction is crucial for timely intervention and improved outcomes.

Purpose of the Study:

  • To develop and validate a simple scoring system, the Multi-Organ Dysfunction in Neonatal Encephalopathy (MODE) score, for quantifying multi-organ injury.
  • To assess the correlation between the MODE score and the severity of NE.
  • To evaluate the predictive value of the MODE score for mortality and long-term neurodevelopmental outcomes.

Main Methods:

  • A scoring system (MODE) was created, assessing cardiovascular, respiratory, gastrointestinal, haematological, and neurological systems (max score 15).
  • The MODE score was compared with NE severity grading and Bayley Scales of Infant Development (Bayley-III) at 2 years.
  • Mortality and adverse outcomes (Bayley score <90 and/or abnormal MRI) were analyzed in relation to MODE scores.

Main Results:

  • Higher MODE scores were significantly associated with moderate/severe NE (NE II/III) compared to mild NE (p < 0.001).
  • The MODE score demonstrated high predictive accuracy for mortality (AUC 0.96, p = 0.002).
  • Elevated MODE scores correlated with abnormal neurological exams at discharge and adverse Bayley-III scores (p = 0.001).

Conclusions:

  • The MODE score provides a valuable tool for quantifying multi-organ injury in NE, aiding early management decisions.
  • The MODE score's strong correlation with mortality and neurodevelopmental outcomes highlights its clinical utility.
  • Future research could explore clinical biomarkers as surrogate endpoints, linking to long-term developmental follow-up in NE clinical trials.