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Flow Cytometric Characterization of Murine B Cell Development
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Signaling networks in B cell development and related therapeutic strategies

Anwen Ren1, Jianxuan Sun2, Wei Yin3

  • 1Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Journal of Leukocyte Biology
|September 16, 2021
PubMed

B cells are essential for Ab production during humoral immune responses. From decades of B cell research, there is now a detailed understanding of B cell subsets, development, functions, and most importantly, signaling pathways. The complicated pathways in B cells and their interactions with each other are stage-dependent, varying with surface marker expression during B cell development. With the increasing understanding of B cell development and signaling pathways, the mechanisms underlying B cell related diseases are being unraveled as well, making it possible to provide more precise and effective treatments. In this review, we describe several essential and recently discovered signaling pathways in B cell development and take a look at newly developed therapeutic strategies targeted at B cell signaling.

Keywords:
B cell developmentBAFFRBCRIL-7Rpre-BCRsignaltherapeutic strategy

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