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Circulating miR-122 in patients with non-toxic acute acetaminophen ingestions

Jacob A Lebin1, Anita Mudan1, Yu Zhang2

  • 1Department of Emergency Medicine, University of California, San Francisco, CA, USA.

Clinical Toxicology (Philadelphia, Pa.)
|September 16, 2021
PubMed

Insights

MicroRNA-122 (miR-122) did not elevate in patients with acute acetaminophen ingestions below toxic levels. This study provides key data on miR-122 patterns in non-toxic acetaminophen exposures.

Area of Science:

  • Biochemistry
  • Toxicology
  • Molecular Biology

Background:

  • MicroRNA-122 (miR-122) is a recognized biomarker for liver injury.
  • miR-122 has been investigated as a potential early predictor of acetaminophen-induced liver toxicity.

Purpose of the Study:

  • To investigate miR-122 levels in patients with acute acetaminophen ingestions below the threshold for hepatotoxicity.
  • To determine if miR-122 elevation occurs in non-toxic acetaminophen exposures.

Main Methods:

  • Observational study of patients with acute acetaminophen ingestion.
  • Measured serum acetaminophen concentrations and miR-122 expression.
  • Compared miR-122 levels in patients below the treatment nomogram with healthy controls.

Main Results:

  • Ten patients with 4-hour acetaminophen concentrations below the nomogram were included (mean 73.4 µg/mL).
  • No significant difference in mean fold change of miR-122 expression was observed between acetaminophen-exposed patients and controls (p=0.33).

Conclusions:

  • miR-122 levels were not elevated in patients with acute acetaminophen ingestions below the nomogram line.
  • These findings contribute to understanding miR-122 behavior in non-toxic acetaminophen exposures.
Keywords:
acetaminophenhepatotoxicitymiR-122

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