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Updated: Oct 20, 2025

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
Published on: May 17, 2024
Incision Location Predicts 30-Day Major Adverse Events after Cosmetic Breast Augmentation: An Analysis of the
Denis S Valente1, Christopher J Pannucci1, Timothy W King1
1From the Mãe de Deus Health System Porto Alegre; Divisions of Plastic Surgery and Services Research, University of Utah; Departments of Surgery and Biomedical Engineering, and Division of Plastic Surgery, University of Alabama at Birmingham; University of Chicago; University of Illinois at Chicago; University of Pittsburgh School of Medicine; Cooper University Hospital; Graduate Program in Medicine and Health Sciences, School of Medicine, Pontifical University Catholic RS; Jawaharlal Institute of Postgraduate Medical Education & Research; Department of Surgery, Joan C. Edwards College of Medicine, Marshall University; University of Missouri-Kansas City School of Medicine; and University of Kansas School of Medicine.
Background:
Enhanced understanding of early postoperative adverse events will improve patient counseling and preoperative risk modification to decrease complications in implant-based breast augmentation. This study seeks to evaluate the early major adverse events following cosmetic breast augmentation.
Methods:
A retrospective cohort analysis of the Tracking Outcomes and Operations for Plastic Surgeons database was performed to identify any women undergoing augmentation mammaplasty with an implant between 2008 and 2016.
Results:
A total of 84,296 patients were studied. Major adverse events were identified in 0.37 percent. Seroma requiring drainage was observed in 0.08 percent, hematoma requiring drainage was observed in 0.15 percent, deep wound disruption was observed in 0.09 percent, and implant loss was observed in 0.11 percent. The authors identified multiple independent predictors of major adverse events, including body mass index greater than 30 kg/m2 (relative risk, 2.05; p < 0.001), tobacco use (relative risk, 2.25; p < 0.001), and diabetes mellitus (relative risk, 1.8; p < 0.05). Use of a periareolar incision significantly increased the risk of developing an early postoperative complication (relative risk, 1.77; p < 0.001).
Conclusions:
The findings of this study indicate an early major adverse event rate following cosmetic breast augmentation with implants of 0.37 percent. The authors identified multiple independent predictors of major adverse events, including body mass index greater than 30 kg/m2, tobacco use, and diabetes mellitus. In addition, when controlling for other factors, periareolar incision significantly increased the risk for major adverse events, when compared to an inframammary incision.
Clinical Question/Level Of Evidence:
Therapeutic, III.

