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THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets.

Stephen Ph Alexander1, Eamonn Kelly2, Alistair Mathie3

  • 1School of Life Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK.

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|September 16, 2021
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Summary
This summary is machine-generated.

The Concise Guide to Pharmacology 2021/22 offers a comprehensive overview of nearly 1900 human drug targets. This essential resource provides key pharmacological information and links to an extensive online knowledgebase for researchers.

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Area of Science:

  • Pharmacology
  • Drug Discovery
  • Biomedical Sciences

Background:

  • The Concise Guide to Pharmacology is a biennial publication series.
  • It serves as a critical reference for drug targets and their properties.

Purpose of the Study:

  • To provide a concise, tabular overview of approximately 1900 human drug targets.
  • To highlight selective pharmacology and link to the comprehensive Guide to Pharmacology knowledgebase (www.guidetopharmacology.org).
  • To offer a permanent, citable record of drug target information.

Main Methods:

  • Compilation of data on human drug targets, focusing on key properties.
  • Categorization into six main areas: G protein-coupled receptors, ion channels, nuclear hormone receptors, catalytic receptors, enzymes, and transporters.
  • Inclusion of 'Other protein targets' outside these categories.

Main Results:

  • Presents information on nearly 1900 human drug targets.
  • Emphasizes selective pharmacology where available.
  • Includes nomenclature guidance, pharmacological tools, references, and further reading suggestions.

Conclusions:

  • The 2021/22 Guide provides an updated, citable snapshot of human drug targets.
  • It facilitates comparison of related targets with data contemporary to mid-2021.
  • Official IUPHAR classification and nomenclature are provided in conjunction with NC-IUPHAR.