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Twenty Years on for The Epithelial-Mesenchymal Transition International Association (TEMTIA): An Interview with

Guojun Sheng1, Erik Thompson2, Donald Newgreen3

  • 1International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan.

Cells, Tissues, Organs
|September 16, 2021
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Breast cancerEpithelial-mesenchymal transitionImplantationNeural crestTEMTIA

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Forced Transdifferentiation01:28

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Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
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