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Identification of Circular RNAs using RNA Sequencing
Published on: November 14, 2019
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circMine: a comprehensive database to integrate, analyze and visualize human disease-related circRNA transcriptome
Wenliang Zhang1,2,3, Yang Liu2,4,5, Zhuochao Min6
1Department of Pediatrics, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong 518053, China.
Nucleic Acids Research
|September 16, 2021
Summary
circMine is a new web resource for analyzing circular RNA (circRNA) transcriptome data. It offers user-friendly tools for researchers to explore circRNA significance in various diseases, aiding discovery.
Area of Science:
- Genomics
- Bioinformatics
- Computational Biology
Background:
- Publicly available circRNA transcriptome data exhibit significant heterogeneity.
- Researchers often lack bioinformatics expertise to analyze complex circRNA datasets.
Purpose of the Study:
- To develop a user-friendly web resource, circMine, for comprehensive analysis of circRNA transcriptome data.
- To facilitate the investigation of clinical and biological significance of circRNAs for researchers of all skill levels.
Main Methods:
- circMine integrates over 1.8 million entries, including 136,871 circRNAs, 87 diseases, and 120 datasets from 1107 samples.
- Provides 13 online analytical functions with standardized and clinically annotated datasets.
- Includes tools for circRNA-miRNA interaction and circRNA translatability analysis.
Main Results:
- circMine enables users to group samples by clinical data and perform custom analyses on their own data.
- Systematic discovery of five potential translatable circRNAs linked to prostate cancer progression.
- Facilitates free browsing, searching, analysis, and downloading of circRNA data.
Conclusions:
- circMine offers a valuable, accessible resource for discovering disease-associated circRNAs.
- Empowers researchers to explore circRNA functions and interactions through intuitive web interfaces.
- Supports data submission for further integration, enhancing the circRNA research community.
