Poly (Adenosine Diphosphate Ribose) Polymerase-1 Single Nucleotide Polymorphism in the 3'-Untranslated Region for
Lujun Gu1, Gangtao Xu1, Dinghua Liu2
1Department of Physical Medicine and Rehabilitation, Jiangyin Fifth People's Hospital, Wuxi 214400, China.
Objective:
To determine the effect of PARP1 polymorphism on gene interactions.
Methods:
A total of 500 patients and 500 healthy controls were enrolled.
Results:
Analysis of clinical data showed that patients with stroke, diabetes, hypertension, and elevated serum triglyceride levels had higher levels of alcohol and smoking. The polymorphism of PARP1rs8679 was inversely associated with the risk of ischemic stroke. Patients with PARP1rs8679AG/ GG genotypes had a lower incidence of an initial stroke. Compared with the wild genotype, mRNA levels of PARP1 were reduced. MiR-124-5p directly induced PARP1 inhibition through the gain binding ability of 3 'UTR binding.
Conclusion:
Single nucleotide polymorphism (SNP) rs8679 in PARP13'UTR can prevent ischemic stroke.
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