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Current Status of Novel Pyridine Fused Derivatives as Anticancer Agents: An Insight into Future Perspectives and

Ajay Manaithiya1, Ozair Alam1, Vrinda Sharma1

  • 1Medicinal Chemistry and Molecular Modelling Lab, Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi-110062, India.

Current Topics in Medicinal Chemistry
|September 17, 2021
PubMed

Insights

Pyrido fused five-membered heterocyclic compounds show significant anticancer potential. This review highlights their therapeutic activity and structure-activity relationships for developing novel cancer drugs.

Area of Science:

  • Medicinal Chemistry
  • Organic Chemistry
  • Pharmacology

Background:

  • Cancer is a leading global cause of death, necessitating novel therapeutic strategies.
  • Heterocyclic compounds, particularly oxygen and nitrogen-based ones, exhibit promising anticancer properties.

Purpose of the Study:

  • To review the anticancer activity of pyrido fused five-membered heterocyclic ring derivatives.
  • To summarize structure-activity relationships of these compounds from 2009-2019.

Main Methods:

  • Literature review focusing on pyrido fused five-membered heterocycles.
  • Analysis of in vitro cytotoxic activity and structure-activity relationships (SAR) of 49 compounds.

Main Results:

  • Identified seven key heterocyclic pyridine fused rings with anticancer potential: Imidazopyridine, Triazolopyridine, Pyrrolopyridine, Pyrazolopyridines, Thienopyridine, and Isoxazolopyridine.
  • Highlighted the role of various pharmacophores and substituents in determining anticancer efficacy.

Conclusions:

  • Pyrido fused five-membered heterocyclic rings represent a promising scaffold for developing new anticancer drugs.
  • Further research into these compounds could lead to effective cancer therapies.
Keywords:
Anticancer activityDockingFuture perspectivesPyridine fused derivativesSARSAR.

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