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Validation of Group-wise Registration for Surface-based Functional MRI Analysis.

Chang Yu1, Yue Liu2,3, Leon Y Cai4

  • 1Department of Computer Science, Vanderbilt University, Nashville, TN, USA.

Proceedings of Spie--The International Society for Optical Engineering
|September 17, 2021
PubMed
Summary

Hierarchical Spherical Deformation (HSD) improves brain surface registration for resting-state functional MRI (rsfMRI) analysis, reducing distortion and enhancing shape correspondence compared to FreeSurfer.

Keywords:
distortionfMRIgroup ICAgroup-wise registrationrsfMRI

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Area of Science:

  • Neuroimaging
  • Brain Mapping
  • Computational Neuroscience

Background:

  • Resting-state functional MRI (rsfMRI) is crucial for brain activity and function studies.
  • Conventional rsfMRI analysis often neglects cortical surface geometry, using Euclidean space registration.
  • Surface-based analysis requires accurate surface registration for group-wise comparisons.

Purpose of the Study:

  • To evaluate and compare two surface registration methods: FreeSurfer and Hierarchical Spherical Deformation (HSD).
  • To assess their performance within a surface-based rsfMRI analysis framework.
  • To investigate neuroanatomical alignment and registration distortion impacting secondary analyses.

Main Methods:

  • Group-wise shape correspondence estimation to minimize registration bias.
  • Comparison of FreeSurfer and HSD in a surface-based rsfMRI analysis.
  • Pilot analysis on imaging data from 100 subjects in an aging cohort.

Main Results:

  • HSD demonstrated significantly improved shape correspondence with 10.94% less mean curvature deviation.
  • HSD achieved substantially reduced registration distortion (18.63%) compared to FreeSurfer (41.91%).
  • HSD introduced less distortion in areas identified by surface-based independent component analysis (ICA).

Conclusions:

  • Hierarchical Spherical Deformation (HSD) offers superior performance for surface-based rsfMRI analysis.
  • HSD minimizes registration bias and distortion, crucial for accurate neuroimaging studies.
  • The findings suggest HSD as a more reliable method for detailed cortical surface analysis.