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Related Concept Videos

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Inflammatory Bowel Disease V: Surgical Management01:21

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Related Experiment Video

Updated: Oct 20, 2025

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Inflammation-Immunity-Nutrition Score: A Novel Prognostic Score for Patients with Resectable Colorectal Cancer.

Xin-Ying Li1, Shuang Yao1, Yang-Ting He1

  • 1Department of Epidemiology and Biostatistics, The Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

Journal of Inflammation Research
|September 17, 2021
PubMed
Summary

A new Inflammation-Immunity-Nutrition score predicts survival in colorectal cancer patients. This score, combining inflammation, immunity, and nutrition markers, is particularly effective for patients with wild type KRAS.

Keywords:
colorectal cancerhigh-sensitivity C-reactive proteininflammationsurvival

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Area of Science:

  • Oncology
  • Clinical Medicine
  • Biomarkers

Background:

  • Colorectal cancer (CRC) prognosis relies on accurate predictive markers.
  • Preoperative inflammation, immune status, and nutritional markers are crucial for CRC outcomes.
  • Combining these factors may offer superior prognostic value.

Purpose of the Study:

  • To evaluate the prognostic significance of a combined Inflammation-Immunity-Nutrition score in resectable colorectal cancer.
  • To assess the score's performance against traditional prognostic indicators.
  • To explore the score's utility in specific patient subgroups, including those with wild type KRAS.

Main Methods:

  • A cohort of 719 patients undergoing colorectal cancer resection was analyzed.
  • The Inflammation-Immunity-Nutrition score (0-6) was derived from preoperative high-sensitivity C-reactive protein, lymphocyte count, and albumin levels.
  • Survival analyses included time-dependent ROC curves, decision curves, Kaplan-Meier curves, Cox regression, and C-indices.

Main Results:

  • A high Inflammation-Immunity-Nutrition score (>2) was associated with significantly worse overall survival (aHR: 3.106) and disease-free survival (aHR: 2.105).
  • The prognostic impact was more pronounced in patients with wild type KRAS (aHR for OS: 4.018).
  • The Inflammation-Immunity-Nutrition score demonstrated superior prognostic performance compared to established markers like modified Glasgow prognostic score, CRP/albumin ratio, PNI, CEA, and CA19-9 for overall survival.

Conclusions:

  • The Inflammation-Immunity-Nutrition score is a potent prognostic tool for overall survival in colorectal cancer patients.
  • Its prognostic value is particularly enhanced in patients with wild type KRAS.
  • This score offers a promising approach for risk stratification and personalized treatment strategies in colorectal cancer management.