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Colon Perforation As Initial Presentation of Refractory and Complicated Sclerosing Mesenteritis

Ammar Haikal1, Kundana Thimmanagari2

  • 1Internal Medicine/Rheumatology, Hackensack Meridian Medical Center, Hackensack, USA.

Cureus
|September 17, 2021
PubMed

Insights

Sclerosing mesenteritis (SM) is a rare, benign fibrosing inflammatory disease of the mesentery. Diagnosis involves CT scans and biopsy, with treatment including surgery and immunosuppressants.

Area of Science:

  • Gastroenterology
  • Pathology

Background:

  • Sclerosing mesenteritis (SM) is a rare condition characterized by chronic inflammation and fibrosis of the mesentery.
  • First described in 1924, SM affects less than 1% of the population.
  • Its exact cause remains unclear, but potential links to gastrointestinal lumen integrity, autoimmune diseases, trauma, malignancy, or surgery are considered.

Observation:

  • The most frequent clinical symptom of SM is abdominal pain.
  • Patients may also experience obstructive symptoms due to the fibrotic process.
  • Diagnostic confirmation typically relies on imaging, specifically CT scans of the abdomen, and histological examination via biopsy.

Findings:

  • SM is a benign, chronic fibrosing inflammatory disease.
  • The disease is rare, with a prevalence below 1%.
  • Potential triggers include altered gastrointestinal lumen integrity from chronic inflammation, autoimmune conditions, trauma, cancer, or surgical procedures.

Implications:

  • Early diagnosis and appropriate treatment are crucial for managing symptoms and preventing complications.
  • Treatment strategies for SM encompass both surgical interventions and the use of immunosuppressive medications.
  • Further research into the etiology of SM may lead to more targeted therapeutic approaches.
Keywords:
colon perforationcomplicated sclerosing mesenteritismesenteritisrefractory sclerosing mesenteritissclerosing mesenteritis

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