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Related Concept Videos

Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

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The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
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Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

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Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

92
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
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Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

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Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
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Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

96
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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Dysrhythmias I: Introduction01:15

Dysrhythmias I: Introduction

241
Dysrhythmias refers to abnormalities in the heart's rhythm. They result from disruptions in the heart's electrical conduction system, which includes the sinoatrial(SA)node, atrioventricular(AV) node, the bundle of His, bundle branches, and Purkinje fibers.Definition and PathophysiologyDysrhythmias result from disorders of impulse formation, impulse conduction, or both. The heart contains specialized cells in the sinoatrial node, atrioventricular node, and the bundle of His and Purkinje fibers...
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Related Experiment Video

Updated: Oct 19, 2025

Development of an Algorithm to Perform a Comprehensive Study of Autonomic Dysreflexia in Animals with High Spinal Cord Injury Using a Telemetry Device
06:51

Development of an Algorithm to Perform a Comprehensive Study of Autonomic Dysreflexia in Animals with High Spinal Cord Injury Using a Telemetry Device

Published on: July 29, 2016

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COVID-19-Associated Dysautonomia.

Krithika Suresh1, Md Didar Ul Alam1, Emily Satkovich1

  • 1Internal Medicine, Conemaugh Memorial Medical Center, Johnstown, USA.

Cureus
|September 17, 2021
PubMed
Summary

Orthostatic hypotension (OH), a drop in blood pressure upon standing, can be caused by COVID-19 related autonomic dysfunction. Treatment with midodrine and fludrocortisone effectively managed OH and falls in a patient with COVID-19.

Area of Science:

  • Neurology
  • Cardiology
  • Infectious Diseases

Background:

  • Orthostatic hypotension (OH) is a significant blood pressure (BP) drop upon standing, often due to impaired autonomic reflexes or volume depletion.
  • Neurological symptoms, including dysautonomia, have been reported in association with coronavirus disease 2019 (COVID-19).

Observation:

  • This report details a case of a patient experiencing OH and recurrent falls.
  • The patient's symptoms were found to be secondary to an underlying COVID-19 infection and associated dysautonomia.

Findings:

  • The patient presented with orthostatic hypotension and recurrent falls.
  • COVID-19 infection was identified as the underlying cause of the patient's dysautonomia and OH.

Implications:

Keywords:
covid-19dysautonomiamidordrineorthostatic hypotensionsyncope

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Last Updated: Oct 19, 2025

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  • This case highlights the potential for COVID-19 to cause or exacerbate orthostatic hypotension through dysautonomia.
  • Successful treatment of OH in this context was achieved using midodrine and fludrocortisone.
  • Further research into the neurological sequelae of COVID-19, particularly concerning autonomic function, is warranted.