Related Experiment Video
Updated: Oct 19, 2025
A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
Published on: November 7, 2017
High Serum Uric Acid and High-Sensitivity C Reactive Protein Concentrations Predict Three-Year Cardiovascular
Quyen Dao Bui Quy1, Tuan Pham Ngoc Huy2, Tuan Nguyen Minh3
1Nephrology, Cho Ray Hospital, Ho Chi Minh, VNM.
Insights
High serum uric acid (UA) and high-sensitivity C-reactive protein (hs-CRP) predict cardiovascular death in continuous ambulatory peritoneal dialysis (CAPD) patients. These biomarkers offer valuable insights for risk stratification in CAPD populations.
Area of Science:
- Nephrology
- Cardiology
- Biomarker Research
Background:
- Cardiovascular disease is a leading cause of mortality in patients undergoing continuous ambulatory peritoneal dialysis (CAPD).
- Identifying reliable predictors of cardiovascular mortality is crucial for improving patient outcomes in CAPD.
- Serum uric acid (UA) and high-sensitivity C-reactive protein (hs-CRP) are potential inflammatory and metabolic markers associated with cardiovascular risk.
Purpose of the Study:
- To evaluate the predictive value of serum uric acid (UA) and high-sensitivity C-reactive protein (hs-CRP) concentrations for three-year cardiovascular-related mortality in CAPD patients.
- To assess the association of elevated UA and hs-CRP levels with cardiovascular mortality risk in this specific patient cohort.
Main Methods:
- A cohort of 267 CAPD patients were enrolled, with measurements of serum UA and hs-CRP.
- Serum UA was determined using an enzymatic colorimetric assay, and hs-CRP was measured via a high-sensitivity particle-enhanced immunoturbidimetric assay.
- Patients were followed for three years, with cardiovascular-related mortality adjudicated by cardiologists and stroke specialists.
Main Results:
- Elevated serum UA (mean 415.16 ± 84.28 µmol/L) was observed in 58.4% of patients, and elevated hs-CRP (median 2 [1-4] mg/L) in 12.4%.
- During the 36-month follow-up, 41 patients (15.4%) experienced cardiovascular-related mortality.
- Cox regression analysis identified hypertension, diabetes, high serum UA, and high hs-CRP as significant risk factors for cardiovascular mortality (p<0.05). ROC analysis indicated predictive value for both UA (AUC=0.822) and hs-CRP (AUC=0.834).
Conclusions:
- Elevated serum uric acid and hs-CRP levels are significant predictive factors for cardiovascular-related mortality in patients undergoing CAPD.
- These biomarkers can aid in identifying CAPD patients at higher risk of cardiovascular events.
- The findings underscore the importance of monitoring UA and hs-CRP in CAPD patients for cardiovascular risk assessment.
Aims:
This study aims to access the predicting value of serum uric acid (UA) and high-sensitivity C reactive protein (hs-CRP) concentration on three-year cardiovascular-related mortality in patients performing continuous ambulatory peritoneal dialysis (CAPD).
Methods:
A total of267 CAPD patients [150 male (56.2%); mean age 48.93 ± 13.58 years] were included in our study. All patients had measured serum UA and hs-CRP concentration. A high-sensitivity particle-enhanced immunoturbidimetric assay determined serum hs-CRP; serum UA levels were determined using an enzymatic colorimetric assay. All patients were followed for three years to detect cardiovascular-related mortality by cardiologists and stroke specialists.
Results:
Mean serum UA level was 415.16 ± 84.28 µmol/L, 58.4% of patients had increased serum UA level. Median serum hs-CRP level was 2 (1-4) mg/L, 12.4% of patients had increased serum hs-CRP level. During 36 months of follow-up, 41 patients (15.4%) had cardiovascular-related mortality. The results of Cox proportional hazards regression showed that hypertension, diabetes, high serum UA and hs-CRP were risk factors that related to cardiovascular-related mortality (p<0.05). The receiver operating characteristic (ROC) curve and Kaplan-Meier analysis results showed that UA and hs-CRP level had predictive value for three-year cardiovascular-related mortality in CAPD patients [uric acid: area under the curve (AUC)=0.822; hs-CRP: AUC=0.834, p < 0.001].
Conclusion:
High serum UA and hs-CRP levels were predictive factors of cardiovascular-related mortality in CAPD patients.
More Related Videos
07:11Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis
Published on: July 19, 2018
05:16Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
Published on: June 10, 2025
Related Concept Videos
01:28Chronic Kidney Disease III: Interprofessional Care
01:26Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:25Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications
01:30Continuous Renal Replacement Therapy
01:28Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration