Related Experiment Video
Updated: Oct 19, 2025
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Correlation between thyroid autoantibodies and cardiovascular disease in patients with stages 3-5 chronic kidney
Weicheng Xu1,2, Shiyi Liang1, Yuxiang Huang3
1Department of Nephrology, Institute of Nephrology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
Insights
Thyroid autoantibodies are linked to cardiovascular disease risks in chronic kidney disease (CKD) patients, particularly affecting triglycerides, anemia, and inflammation. Female CKD patients with high thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TGAb) titers require attention.
Area of Science:
- Nephrology
- Endocrinology
- Cardiology
Background:
- Chronic kidney disease (CKD) is frequently comorbid with thyroid and cardiovascular diseases (CVD).
- The association between thyroid autoantibodies and cardiac/renal function in CKD patients remains underexplored.
Purpose of the Study:
- To investigate the relationship between thyroid autoantibodies and cardiac/renal function in patients with stages 3-5 CKD.
Main Methods:
- A cross-sectional study involving 1,164 CKD patients (stages 3-5).
- Collected clinical data, laboratory indexes, and echocardiographic parameters (e.g., E/E' ratio, LVEF).
Main Results:
- Thyrotropin receptor antibody (TRAb) correlated positively with C-reactive protein.
- Thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TGAb) titers were higher in male diabetic patients and negatively correlated with hemoglobin in female patients.
- TPOAb positivity was associated with higher E/E' ratio and LVEF, while TRAb negatively correlated with LVEF.
Conclusions:
- Autoimmune thyroid disease (AITD) may elevate CVD risk in CKD patients via triglyceride levels, anemia, and micro-inflammation.
- Female patients with elevated TPOAb and TGAb warrant close monitoring.
- TPOAb-positive women may have an increased risk of diastolic heart failure.
Background:
Chronic kidney disease (CKD) is associated with thyroid disease and cardiovascular disease (CVD). To date, little is known about the association of thyroid autoantibodies with renal function or cardiac function in patients with CKD.
Methods:
This is a descriptive cross-sectional study. Patients diagnosed with stages 3-5 CKD from January 2015 to May 2019 at our department were recruited. Routine medical history, general clinical data, and laboratory test indexes were collected for all patients. Echocardiography was performed by a trained echocardiographer to measure E in early diastole and A, E/A ratio, E' in early diastole, A' in end-diastole, E/E' ratio, and E'/A' ratio.
Results:
A total of 1,164 patients with stages 3-5 CKD were included. Thyrotropin receptor antibody (TRAb) was significantly positively correlated with C-reactive protein (r=0.206, P<0.001). Thyroid peroxidase antibody (TPOAb) and TGAb titers in male diabetic patients were higher (r=0.137, P=0.023; r=0.159, P=0.011). In female patients, both TPOAb and TGAb were significantly negatively correlated with hemoglobin (r=-0.213, P=0.018; r=-0.188, P=0.019). The E/E' of patients who were TPOAb positive was higher than that in patients with TPOAb negative (r=0.181, P<0.001). LVEF in patients who were TPOAb positive was higher than that in patients with TPOAb negative (r=0.159, P=0.007). In addition, LVEF was significantly negatively correlated with TRAb (r=-0.112, P=0.026).
Conclusions:
In patients with stages 3-5 CKD, AITD may increase the risk of CVD in CKD patients by affecting triglycerides levels, increasing the risk of anemia, and promoting micro-inflammation. Attention should be paid to female patients with high TPOAb and TGAb titers. The mean of E/E' in patients with stage 5 CKD was 16.89 in the present study. Women with TPOAb positive may be more likely to develop diastolic heart failure.
Related Concept Videos
01:24Chronic Kidney Disease II: Clinical Manifestations
01:28Chronic Kidney Disease III: Interprofessional Care
01:25Chronic Kidney Disease I: Introduction
01:29Acute Kidney Injury III: Clinical Manifestations
01:18Chronic Kidney Disease IV: Nursing Management
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention