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Updated: Oct 19, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

9.7K

P53-regulated autophagy and its impact on drug resistance and cell fate

Daeun Shim1, Lei Duan1, Carl G Maki1

  • 1Department of Cell and Molecular Medicine, Rush University Medical Center, Chicago, IL 60612, USA.

Cancer Drug Resistance (Alhambra, Calif.)
|September 17, 2021
PubMed

Insights

The tumor suppressor p53 influences autophagy, a cellular recycling process. Modulating autophagy can enhance p53

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Cancer Research

Background:

  • Wild-type p53 functions as a tumor suppressor by halting cancer cell growth via apoptosis or proliferation arrest.
  • Autophagy is a cellular degradation and recycling process crucial for stress response and survival.
  • The p53 protein's role in autophagy is context-dependent, influenced by its location, mutation status, and stress levels.

Purpose of the Study:

  • To investigate the intricate relationship between p53 and autophagy in cancer.
  • To explore how autophagy modulation impacts p53-mediated tumor suppression.

Main Methods:

  • Literature review and analysis of existing studies on p53 and autophagy.
  • Examination of experimental data linking p53 activity, autophagy flux, and cell fate.

Main Results:

  • P53 can either promote or inhibit autophagy based on cellular context.
  • Inhibition of autophagy has been shown to potentiate p53-induced apoptosis in cancer cells.

Conclusions:

  • Autophagy plays a significant role in determining cell fate when p53 is activated.
  • Targeting autophagy presents a potential strategy to augment p53-driven tumor suppression.
Keywords:
Autophagyhistone methylationmetabolism

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