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Diffuse large B-cell lymphoma: a consensus practice statement from the Australasian Lymphoma Alliance

Joel Wight1,2,3,4, Nada Hamad5,6,7, Belinda A Campbell8,9,10

  • 1Department of Haematology and Bone Marrow Transplantation, Townsville University Hospital, Townsville, Queensland, Australia.

Internal Medicine Journal
|September 17, 2021
PubMed

Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma subtype, accounting for 30-40% of lymphoma diagnoses. Although aggressive, cure is achievable in approximately 60% of cases with primary chemoimmunotherapy, and in a further substantial minority by salvage therapy and autologous stem cell transplantation. Despite promising activity in early phase clinical trials, no intensified or novel treatment regimen has improved outcomes over R-CHOP21 in randomised studies. However, there remain several areas of controversy including the most appropriate prognostic markers, central nervous system prophylaxis and the optimal treatment for patients with high-risk disease. This position statement presents an evidence-based synthesis of the literature for application in Australasian practice.

Keywords:
diagnosisdiffuse large B-cell lymphomamanagementprognosis

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